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呼吸道合胞病毒G糖蛋白和/或SH糖蛋白可改变BALB/c小鼠中CC趋化因子和CXC趋化因子的mRNA表达。

Respiratory syncytial virus G and/or SH glycoproteins modify CC and CXC chemokine mRNA expression in the BALB/c mouse.

作者信息

Tripp R A, Jones L, Anderson L J

机构信息

Division of Viral and Rickettsial Diseases, National Center of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.

出版信息

J Virol. 2000 Jul;74(13):6227-9. doi: 10.1128/jvi.74.13.6227-6229.2000.

DOI:10.1128/jvi.74.13.6227-6229.2000
PMID:10846112
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC112127/
Abstract

Chemokine mRNA expression by pulmonary leukocytes following infection of BALB/c mice with two strains of respiratory syncytial virus (RSV) and one strain of parainfluenza virus type 3 (PIV-3) was determined. The results suggest that RSV G and/or SH proteins inhibit early MIP-1alpha, MIP-1beta, MIP-2, MCP-1, and IP-10 mRNA expression. TCA-3 mRNA expression was found to be increased during PIV-3 infection.

摘要

测定了用两株呼吸道合胞病毒（RSV）和一株3型副流感病毒（PIV - 3）感染BALB/c小鼠后，肺白细胞中趋化因子mRNA的表达。结果表明，RSV G和/或SH蛋白抑制早期MIP - 1α、MIP - 1β、MIP - 2、MCP - 1和IP - 10 mRNA的表达。发现TCA - 3 mRNA表达在PIV - 3感染期间增加。

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本文引用的文献

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Chemokines: a new classification system and their role in immunity.趋化因子：一种新的分类系统及其在免疫中的作用。
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Secreted respiratory syncytial virus G glycoprotein induces interleukin-5 (IL-5), IL-13, and eosinophilia by an IL-4-independent mechanism.分泌型呼吸道合胞病毒G糖蛋白通过不依赖白细胞介素-4的机制诱导白细胞介素-5（IL-5）、白细胞介素-13和嗜酸性粒细胞增多。
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T helper cell type 2 cytokine-mediated comitogenic responses and CCR3 expression during differentiation of human mast cells in vitro.人肥大细胞体外分化过程中2型辅助性T细胞细胞因子介导的促有丝分裂反应及CCR3表达
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Regulation of CCR5 and CXCR4 expression by type 1 and type 2 cytokines: CCR5 expression is downregulated by IL-10 in CD4-positive lymphocytes.1型和2型细胞因子对CCR5和CXCR4表达的调控：在CD4阳性淋巴细胞中，白细胞介素-10可下调CCR5的表达。
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