Woolf C J, Salter M W
Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, MGH-East, Charlestown, MA 02129, USA.
Science. 2000 Jun 9;288(5472):1765-9. doi: 10.1126/science.288.5472.1765.
We describe those sensations that are unpleasant, intense, or distressing as painful. Pain is not homogeneous, however, and comprises three categories: physiological, inflammatory, and neuropathic pain. Multiple mechanisms contribute, each of which is subject to or an expression of neural plasticity-the capacity of neurons to change their function, chemical profile, or structure. Here, we develop a conceptual framework for the contribution of plasticity in primary sensory and dorsal horn neurons to the pathogenesis of pain, identifying distinct forms of plasticity, which we term activation, modulation, and modification, that by increasing gain, elicit pain hypersensitivity.
我们将那些令人不适、强烈或痛苦的感觉描述为疼痛。然而，疼痛并非单一的，它包括三类：生理性疼痛、炎症性疼痛和神经性疼痛。多种机制参与其中，每种机制都受到神经可塑性的影响或表现为神经可塑性——神经元改变其功能、化学特征或结构的能力。在此，我们构建了一个概念框架，用于阐述初级感觉神经元和背角神经元中的可塑性在疼痛发病机制中的作用，识别出可塑性的不同形式，我们将其称为激活、调制和修饰，这些形式通过增加增益引发疼痛超敏反应。
