Barreiro E, Rubio M, Felisart F, Terrades J, Marcos R, Gea J
Sección de Neumología, Hospital Universitario de Girona.
Arch Bronconeumol. 2000 Apr;36(4):172-9. doi: 10.1016/s0300-2896(15)30177-0.
Bronchial asthma is a chronic disease whose prevalence and severity is increasing. Appropriate treatment of exacerbation seems to affect the subsequent course of disease.
To assess the extent of application of guidelines for treating exacerbations of asthma and to describe the clinical and epidemiological characteristics of patients.
All patients presenting with exacerbations to the emergency room of a referral hospital in a semi-rural area of Catalonia were enrolled consecutively. We recorded symptoms, function and treatment variables during the emergency and when the patient was stable, at which time we also administered the Asthma Quality of Life Questionnaire (AQLQ).
Forty-seven percent of patients resided in rural villages. Seventy-one percent lived in the area served by our hospital. Of the remaining patients, 57% came from municipalities in the Baix Empordà area, 29% in Alt Empordà area and 14% in La Selva area. Seventy-one percent went to the hospital directly from home, 66% of them were in the province of Girona; 75% of those homes were within urban areas. Of the 29% who had been sent to the emergency room by a physician, 71% were from a rural area. The 119 asthma exacerbations treated (114 patients, 71 females, 42 +/- 23 years) accounted for 0.3% of all emergency room visits. The exacerbation was considered severe in 31%, moderate in 47% and mild in all remaining cases. Eighty-eight percent of patients had experienced an exacerbation before. Symptoms were often present before the attack, but nearly half the patients were receiving relatively inadequate medication. Peak expiratory flow and oxygen saturation were recorded in 70% of cases and both variables improved after initial treatment (250 +/- 97 to 349 +/- 92 l/min, p < 0.001; and 92 +/- 7 to 96 +/- 2%, p < 0.01, respectively). All patients received inhaled salbutamol, 44% inhaled corticosteroids and 73% intravenous corticosteroids. A quarter of the patients were admitted to the ward (0.4% of all admissions) and 4% were admitted to the intensive care unit. Patients stayed 8.8 +/- 1.4 h in the emergency room. When patients were stable, asthma was severe in 14%, moderate in 42%, mild but persistent in 27%, and occasional in 17%. The total score on the AQLQ was 13.8 +/- 11.1, with mood being the dimension with the highest score (5.1 +/- 4.9). This score, along with social restriction, were lowest in the group of patients with chronic airflow obstruction.
Nearly half the patients were from rural villages most of which were located outside the zone served directly by our hospital. The preference for specialized medical attention would explain the percentage of patients seen who did not belong to the assigned area. Difficulty of access to the hospital from certain rural areas would account for the greater number of rural patients who had been referred by a physician. Clinical management and monitoring of asthmatic patients with exacerbation could be improved by greater diffusion and application of guidelines. It would be interesting to incorporate come sort of questionnaire on quality of life while taking a patient's history.
支气管哮喘是一种患病率和严重程度都在上升的慢性疾病。对病情加重的适当治疗似乎会影响疾病的后续进程。
评估哮喘病情加重治疗指南的应用程度,并描述患者的临床和流行病学特征。
连续纳入加泰罗尼亚一个半农村地区一家转诊医院急诊室中所有出现病情加重的患者。我们记录了急诊期间以及患者病情稳定时的症状、功能和治疗变量,在病情稳定时还对患者进行了哮喘生活质量问卷(AQLQ)测评。
47%的患者居住在农村村庄。71%居住在我院服务区域内。其余患者中,57%来自下恩波达地区的市镇,29%来自上恩波达地区,14%来自拉塞尔瓦地区。71%的患者直接从家中前来医院,其中66%来自赫罗纳省;这些患者中75%的家位于市区。在由医生送往急诊室的29%的患者中,71%来自农村地区。共治疗了119例哮喘病情加重患者(1例患者有2次病情加重,114名患者,71名女性,42±23岁),占所有急诊就诊病例的0.3%。31%的病情加重被认为严重,47%为中度,其余为轻度。88%的患者之前曾有过病情加重。发作前常有症状,但近一半患者接受的药物治疗相对不足。70%的病例记录了呼气峰值流速和血氧饱和度,初始治疗后这两个变量均有所改善(分别从250±97升至349±92升/分钟,p<0.001;从92±7升至96±2%,p<0.01)。所有患者均接受了吸入沙丁胺醇治疗,44%接受了吸入糖皮质激素治疗,73%接受了静脉糖皮质激素治疗。四分之一的患者被收入病房(占所有住院患者的0.4%),4%的患者被收入重症监护病房。患者在急诊室停留8.8±1.4小时。患者病情稳定时,14%为重度哮喘,42%为中度,27%为轻度但持续存在,17%为偶尔发作。AQLQ总分13.8±11.1,情绪维度得分最高(5.1±4.9)。该得分以及社会限制在慢性气流受限患者组中最低。
近一半患者来自农村村庄,其中大部分位于我院直接服务区域之外。对专科医疗关注的偏好可以解释就诊患者中不属于指定区域的患者比例。某些农村地区就医困难可以解释由医生转诊的农村患者数量较多的原因。通过更广泛地传播和应用指南,可以改善哮喘病情加重患者的临床管理和监测。在采集患者病史时纳入某种生活质量问卷会很有意义。