Holowiecki J, Stella B, Krawczyk M, Rudzka E
Acta Haematol Pol. 1976;7(2):111-6.
In 40 healthy subjects and 80 patients with chronic lymphocytic leukaemia (CLL) rosette formation test with sheep erythrocytes subjected to the action of neuraminidase (nRTB), immunofluorescent investigation of membrane immunoglobulins (BIg) and a combined test (nRTB + BIg) were performed. The relative number of rosette-forming cells (T lymphocytes) was much lower in the group of CLL patients (0.16 +/- 0.08 1/1) than in controls (0.64 +/- 0.12 1/1). The absolute number of T lymphocytes (BLLT) was, however, significantly higher in patients with CLL 5.1 +/- 4.4 G/L) than in controls (0.98 +/- 0.28 G/L). The relative number of bireceptor cells was 0.0045 +/- 0.0093 1/1 in CLL patients and that of null-cells 0.24 +/- 0.17 1/1. Analogous values in the control group were 0.0089 +/- 0.009 1/1 and 0.21 +/- 0.091 1/1. The possible causes of this rise in the absolute number of T lymphocytes in CLL may by: 1) proliferation of both subpopulations of lymphocytes, 2) reaction of T lymphocytes against leukaemic cells, 3) disturbances of equilibrium between B and T lymphocytes.
对40名健康受试者和80名慢性淋巴细胞白血病（CLL）患者进行了以下检测：用经神经氨酸酶作用的绵羊红细胞进行玫瑰花结形成试验（nRTB）、膜免疫球蛋白的免疫荧光研究（BIg）以及联合试验（nRTB + BIg）。CLL患者组中玫瑰花结形成细胞（T淋巴细胞）的相对数量（0.16±0.08 1/1）远低于对照组（0.64±0.12 1/1）。然而，CLL患者的T淋巴细胞绝对数量（BLLT）（5.1±4.4 G/L）显著高于对照组（0.98±0.28 G/L）。CLL患者中双受体细胞的相对数量为0.0045±0.0093 1/1，空细胞的相对数量为0.24±0.17 1/1。对照组的类似值分别为0.0089±0.009 1/1和0.21±0.091 1/1。CLL患者T淋巴细胞绝对数量增加的可能原因可能是：1）淋巴细胞两个亚群的增殖；2）T淋巴细胞对白血病细胞的反应；3）B淋巴细胞和T淋巴细胞之间平衡的紊乱。
