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金黄色葡萄球菌的蛋白A对B细胞来源的慢性淋巴细胞白血病中T淋巴细胞的刺激作用。

Stimulation of T lymphocytes by protein A from Staphylococcus aureus in B-derived chronic lymphocytic leukaemia.

作者信息

Guglielmi P, Preud'Homme J L

出版信息

Clin Exp Immunol. 1980 Jul;41(1):136-40.

PMID:6969148
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1536914/
Abstract

Peripheral blood lymphocytes from five untreated patients affected with B-derived chronic lymphocytic leukaemia were stimulated by protein A from Staphylococcus aureus. A very strong response (with stimulation indexes as high as 182 and percentages of blast cells as high as 90%) was found in all patients. Lymphocyte marker studies showed that the responding cells were T cells. These results and the well known abnormalities of lymphocyte response to other mitogens suggest a disbalance of T lymphocyte subpopulations in B-CLL.

摘要

来自五名未经治疗的B细胞慢性淋巴细胞白血病患者的外周血淋巴细胞受到金黄色葡萄球菌蛋白A的刺激。在所有患者中均发现了非常强烈的反应（刺激指数高达182，母细胞百分比高达90%）。淋巴细胞标志物研究表明，反应细胞为T细胞。这些结果以及淋巴细胞对其他有丝分裂原反应的众所周知的异常情况表明，B细胞慢性淋巴细胞白血病中T淋巴细胞亚群失衡。

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Formalin-treated bacteria as selective B cell mitogens: results in primary and acquired immunodeficiencies.经福尔马林处理的细菌作为选择性B细胞有丝分裂原：导致原发性和获得性免疫缺陷。
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本文引用的文献

1
Isolation of normal T cells in chronic lymphatic leukaemia.慢性淋巴细胞白血病中正常T细胞的分离
Lancet. 1973 Jan 20;1(7795):126-9. doi: 10.1016/s0140-6736(73)90196-7.
2
Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells.人类T和B淋巴细胞的表面标志物。I. 大量与绵羊红细胞形成非免疫性玫瑰花结的淋巴细胞。
J Exp Med. 1972 Aug 1;136(2):207-15. doi: 10.1084/jem.136.2.207.
3
Response of lymphocytes in chronic lymphocytic leukaemia to plant mitogens.慢性淋巴细胞白血病中淋巴细胞对植物有丝分裂原的反应。
Lancet. 1972 Jan 29;1(7744):229-33. doi: 10.1016/s0140-6736(72)90624-1.
4
Lymphocyte stimulation by protein A of Staphylococcus aureus.金黄色葡萄球菌蛋白A对淋巴细胞的刺激作用。
Eur J Immunol. 1976 Mar;6(3):207-13. doi: 10.1002/eji.1830060312.
5
Impaired T-cell transformation in chronic lymphocytic leukemia (CLL): Demonstration of a blastogenesis inhibitory factor.慢性淋巴细胞白血病（CLL）中T细胞转化受损：一种增殖抑制因子的证明
Blood. 1975 Dec;46(6):883-90.
6
Activation of lymphocytes in CLL by protein A from Staphylococcus aureus.金黄色葡萄球菌蛋白A对慢性淋巴细胞白血病中淋巴细胞的激活作用。
Clin Exp Immunol. 1978 Nov;34(2):188-92.
7
T cell helper defect in patients with chronic lymphocytic leukemia.慢性淋巴细胞白血病患者的T细胞辅助缺陷。
J Immunol. 1979 Mar;122(3):1087-90.
8
The polyclonal B-cell-activating property of protein A is not due to its interaction with the FC part of immunoglobulin receptors.蛋白A的多克隆B细胞激活特性并非因其与免疫球蛋白受体的Fc部分相互作用所致。
Scand J Immunol. 1977;6(4):357-66. doi: 10.1111/j.1365-3083.1977.tb00405.x.
9
PHA-induced soluble factor(s) can activate B-cells from patients with chronic lymphatic leukaemia.PHA诱导的可溶性因子可激活慢性淋巴细胞白血病患者的B细胞。
Clin Exp Immunol. 1979 Sep;37(3):517-22.
10
Protein A from Staphylococcus aureus-a mitogen for human T lymphocytes and B lymphocytes but not L lymphocytes.来自金黄色葡萄球菌的蛋白A——一种人类T淋巴细胞和B淋巴细胞而非L淋巴细胞的促有丝分裂原。
J Immunol. 1978 Jan;120(1):302-11.

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