金黄色葡萄球菌的蛋白A对B细胞来源的慢性淋巴细胞白血病中T淋巴细胞的刺激作用。

Stimulation of T lymphocytes by protein A from Staphylococcus aureus in B-derived chronic lymphocytic leukaemia.

作者信息

Guglielmi P, Preud'Homme J L

出版信息

Clin Exp Immunol. 1980 Jul;41(1):136-40.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1536914/

Abstract

Peripheral blood lymphocytes from five untreated patients affected with B-derived chronic lymphocytic leukaemia were stimulated by protein A from Staphylococcus aureus. A very strong response (with stimulation indexes as high as 182 and percentages of blast cells as high as 90%) was found in all patients. Lymphocyte marker studies showed that the responding cells were T cells. These results and the well known abnormalities of lymphocyte response to other mitogens suggest a disbalance of T lymphocyte subpopulations in B-CLL.

摘要

来自五名未经治疗的B细胞慢性淋巴细胞白血病患者的外周血淋巴细胞受到金黄色葡萄球菌蛋白A的刺激。在所有患者中均发现了非常强烈的反应（刺激指数高达182，母细胞百分比高达90%）。淋巴细胞标志物研究表明，反应细胞为T细胞。这些结果以及淋巴细胞对其他有丝分裂原反应的众所周知的异常情况表明，B细胞慢性淋巴细胞白血病中T淋巴细胞亚群失衡。

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