Dalmau J
Department of Neurology, Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock, USA.
Neurologia. 2000 Mar;15(3):114-26.
For many years paraneoplastic neurological syndromes have been identified through the exclusion of other neurological complications in patients with cancer. The discovery that many paraneoplastic syndromes are associated with immunological reactions allows a specific and comprehensive definition of these disorders, which often can be promptly recognized by the serological detection of antineuronal antibodies. In a significant number of paraneoplastic syndromes the genes coding for the target onconeuronal antigens have been cloned and their functions are being elucidated. This study reviews the pathogenic mechanisms of paraneoplastic neurological syndromes and addresses the most frequently asked questions regarding their diagnosis and treatment.
多年来，副肿瘤性神经综合征是通过排除癌症患者的其他神经并发症来确定的。许多副肿瘤综合征与免疫反应相关这一发现，使得对这些疾病有了具体而全面的定义，这些疾病通常可以通过抗神经元抗体的血清学检测迅速识别出来。在相当数量的副肿瘤综合征中，编码靶标肿瘤神经抗原的基因已被克隆，其功能也正在阐明。本研究回顾了副肿瘤性神经综合征的致病机制，并解答了有关其诊断和治疗的最常见问题。
