Hammond S R, McLeod J G, Macaskill P, English D R
Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, University of Sydney, Australia.
J Clin Neurosci. 2000 Jan;7(1):16-9. doi: 10.1054/jocn.1998.0107.
In order to determine the influence of age of onset, sex, onset symptoms, clinical course and interval from onset to first relapse on the subsequent outcome of multiple sclerosis (MS), data from 2934 cases of MS documented in a large population based study undertaken in Australia have been analysed. Disability on prevalence day (30 June 1981) was defined on the Kurtzke disability scale as mild (DSS 0-3), moderate (DSS 4-6) and severe (DSS 7-9). Prognostic factors associated with mild vs moderate/severe, and moderate vs severe disability on prevalence day were identified by logistic regression analysis. A worse prognosis was significantly associated with older age of onset, progressive disease course, onset symptoms that were multiple, pyramidal or cerebellar, and a short interval between onset and first relapse.
为了确定发病年龄、性别、起病症状、临床病程以及从发病到首次复发的间隔时间对多发性硬化症（MS）后续转归的影响，我们分析了在澳大利亚进行的一项基于大样本人群研究中记录的2934例MS患者的数据。将患病日（1981年6月30日）的残疾程度按照库茨克残疾量表定义为轻度（残疾状态评分0 - 3）、中度（残疾状态评分4 - 6）和重度（残疾状态评分7 - 9）。通过逻辑回归分析确定了与患病日轻度与中度/重度残疾以及中度与重度残疾相关的预后因素。预后较差与发病年龄较大、疾病呈进展性病程、起病症状为多种、锥体束或小脑症状以及发病到首次复发间隔时间短显著相关。
