Okamoto K, Kukita I, Hamaguchi M, Motoyama T, Muranaka H, Harada T
Division of Intensive and Critical Care Medicine, Kumamoto University School of Medicine, Kumamoto, Japan.
Artif Organs. 2000 May;24(5):390-5. doi: 10.1046/j.1525-1594.2000.06496-3.x.
We studied the combined effects of inhaled nitric oxide (INO) and positive end expiratory pressure (PEEP) during mechanical ventilation in patients with acute respiratory distress syndrome (ARDS). Eleven patients received 0 and 4 parts per million of INO in random order for 30 min at PEEP levels of 0, 5, and 10 cm H2O. Respiratory and cardiovascular parameters were measured. The addition of INO and PEEP significantly improved arterial oxygenation (p < 0.005 and p < 0.0001, respectively). The combined effect of INO and PEEP on arterial oxygenation was remarkable during 10 cm H2O PEEP. There was synergistic effect on arterial oxygenation by combining INO and 10 cm H2O PEEP. The present study showed that the combination of INO and 10 cm H2O PEEP enhanced arterial oxygenation in patients with ARDS.
我们研究了在急性呼吸窘迫综合征（ARDS）患者机械通气期间吸入一氧化氮（INO）和呼气末正压（PEEP）的联合作用。11名患者在PEEP水平为0、5和10 cm H2O时，以随机顺序接受0和4 ppm的INO，持续30分钟。测量呼吸和心血管参数。添加INO和PEEP显著改善了动脉氧合（分别为p < 0.005和p < 0.0001）。在10 cm H2O PEEP期间，INO和PEEP对动脉氧合的联合作用显著。联合INO和10 cm H2O PEEP对动脉氧合有协同作用。本研究表明，联合INO和10 cm H2O PEEP可增强ARDS患者的动脉氧合。
