De Silva B D, McLaren K, Kavanagh G M
Departments of Dermatology and Pathology, The Royal Infirmary of Edinburgh, Lauriston Place, Edinburgh EH3 9YW, U.K.
Br J Dermatol. 2000 Jun;142(6):1221-7. doi: 10.1046/j.1365-2133.2000.03555.x.
We report two patients who satisfied the diagnostic criteria for actinic reticuloid (AR) on initial presentation, in whom genotypic analysis of early skin biopsies failed to show T-cell gene receptor rearrangements. Both patients progressed to widespread skin involvement associated with histopathological and genotypic features of mycosis fungoides (MF). Arguably, these patients may have had photosensitive MF from the outset, but their clinical features, phototesting, and subsequent demonstration of a T-cell gene receptor rearrangement in the skin could also suggest progression of AR to MF.
我们报告了两名患者，他们初诊时符合光化性类网状细胞增多症（AR）的诊断标准，早期皮肤活检的基因分型分析未显示T细胞基因受体重排。两名患者均进展为广泛的皮肤受累，并伴有蕈样肉芽肿（MF）的组织病理学和基因特征。可以说，这些患者可能从一开始就患有光敏性MF，但其临床特征、光试验以及随后皮肤中T细胞基因受体重排的证实也可能提示AR进展为MF。
