Harada H, Miura K, Tsutsui Y, Mineta H, Urano M, Abe M, Kuroda M, Kasahara M
Division of Pathology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Pathol Int. 2000 May;50(5):431-9. doi: 10.1046/j.1440-1827.2000.01055.x.
A rare case of recurrent respiratory papillomatosis (RRP) is reported with a review of the literature. A 40-year-old Japanese woman had suffered from RRP since 1 year of age. She developed a pulmonary squamous papilloma with a thin-walled cavity, which was suspected as being lung carcinoma. The trachea and bronchi around the tumor were intact, and no malignant transformation was present. Two types of human papillomavirus, 6 and 16, were detected, both in the laryngeal and pulmonary papillomas by in situ hybridization and the polymerase chain reaction method. To date, only 40 cases of juvenile laryngeal papilloma with pulmonary involvement have been reported in the English literature.
本文报告一例罕见的复发性呼吸道乳头状瘤病（RRP）并对文献进行综述。一名40岁日本女性自1岁起就患有RRP。她患上了一个带有薄壁空洞的肺鳞状乳头状瘤，曾被怀疑为肺癌。肿瘤周围的气管和支气管完好无损，不存在恶性转化。通过原位杂交和聚合酶链反应方法，在喉部和肺部乳头状瘤中均检测到两种人乳头瘤病毒，即6型和16型。迄今为止，英文文献中仅报道了40例累及肺部的青少年喉乳头状瘤病例。
