Doyle D J, Henderson L A, LeJeune F E, Miller R H
Department of Otolaryngology-Head and Neck Surgery, Tulane Medical School, New Orleans, La.
Arch Otolaryngol Head Neck Surg. 1994 Nov;120(11):1273-6. doi: 10.1001/archotol.1994.01880350079014.
A patient with recurrent respiratory papillomatosis progressed spontaneously to carcinoma resulting in death. Serial biopsy specimens obtained during a 9-year course of this patient's disease were tested via polymerase-chain reaction and Southern hybridization to detect the human papillomavirus (HPV) types present during the patient's course of disease. Early biopsy specimens were positive for HPV types 6 and 11. As atypia progressed to carcinoma, HPV types 6 and 11 remained present, but the signal decreased and HPV 16 became increasingly positive. The significance of these findings will be discussed.
一名复发性呼吸道乳头状瘤病患者自发进展为癌并导致死亡。在该患者9年病程中获取的系列活检标本通过聚合酶链反应和Southern杂交进行检测，以检测患者病程中存在的人乳头瘤病毒（HPV）类型。早期活检标本HPV 6型和11型呈阳性。随着异型增生进展为癌，HPV 6型和11型仍然存在，但信号减弱，而HPV 16型变得越来越阳性。将讨论这些发现的意义。
