Yamana K, Sano T, Suzuki N, Kojima J, Onodera K
Pharmaceutical Discovery Group 2, Omiya Research Laboratory, Nikken Chemicals Co., Saitama, Japan.
Methods Find Exp Clin Pharmacol. 2000 Mar;22(2):97-100. doi: 10.1358/mf.2000.22.2.796071.
The antiasthmatic effect of i.v. injection of theophylline was compared with that of aminophylline by using an antigen-induced bronchoconstriction model in sensitized guinea pigs. Both theophylline and aminophylline showed dose-dependent inhibition of antigen-induced bronchoconstriction. Statistically significant differences were observed at theophylline doses of 20 and 40 mg/kg and at aminophylline doses of 25 and 50 mg/kg. Thus, antiasthmatic effects of both drugs appeared to be similar. In addition, intravenous ethylenediamine did not influence either airflow in normal guinea pigs or bronchoconstriction induced by antigen at doses up to 30 mg/kg. In conclusion, the ethylenediamine in aminophylline may not influence the antiasthmatic action of theophylline, and the therapeutic effects of theophylline and aminophylline are suggested to be similar.
通过在致敏豚鼠中使用抗原诱导的支气管收缩模型，比较了静脉注射茶碱与氨茶碱的抗哮喘作用。茶碱和氨茶碱均显示出对抗原诱导的支气管收缩的剂量依赖性抑制作用。在茶碱剂量为20和40mg/kg以及氨茶碱剂量为25和50mg/kg时观察到统计学上的显著差异。因此，两种药物的抗哮喘作用似乎相似。此外，静脉注射乙二胺在剂量高达30mg/kg时，对正常豚鼠的气流或抗原诱导的支气管收缩均无影响。总之，氨茶碱中的乙二胺可能不影响茶碱的抗哮喘作用，茶碱和氨茶碱的治疗效果提示相似。
