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[创伤后血管痉挛及其尼莫地平治疗]

[Posttraumatic vasospasm and its treatment with nimodipine].

作者信息

Abraszko R, Zub L, Mierzwa J, Berny W, Wroński J

机构信息

Katedry i Kliniki Neurochirurgii AM we Wrocławiu.

出版信息

Neurol Neurochir Pol. 2000 Jan-Feb;34(1):113-20.

PMID:10849909
Abstract

The aim of our study was to compare the incidence and the time course of vasospasm as well as outcome of patients with tSAH. In group I there were 15 patients treated with nimodipine. Group II consisted of 20 patients in whom nimodipine was not used. All patients suffered from severe head injury, scored 8 points or less according to Glasgow Coma Scale. The initial CT scan revealed tSAH in all of them. Outcome was evaluated according to Glasgow Outcome Scale (GOS) three months after injury. Results were better (but not significantly) in patients in whom nimodipine was used, time course of vasospasm was less severe and follow-up CT scans did not reveal ischaemic infarcts connected with vasospasm.

摘要

我们研究的目的是比较创伤性蛛网膜下腔出血(tSAH)患者血管痉挛的发生率、时间进程以及预后情况。第一组有15例接受尼莫地平治疗的患者。第二组由20例未使用尼莫地平的患者组成。所有患者均遭受严重颅脑损伤,根据格拉斯哥昏迷量表评分8分或更低。初始CT扫描显示他们均有tSAH。根据格拉斯哥预后量表(GOS)在受伤三个月后评估预后。使用尼莫地平的患者结果更好(但无显著差异),血管痉挛的时间进程较轻,随访CT扫描未发现与血管痉挛相关的缺血性梗死。

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