Grigor'ian A S, Volozhin A I, Agapov V S, Belozerov M N, Drobyshev A Iu
Stomatologiia (Mosk). 2000;79(3):4-8.
Time course of healing of induced defects in the femoral bone filled with various forms of hydroxyapatite (HA) was studied in experimental rats on days 30, 60, and 90 after inflicting the defect. HA granulate exerted the best effect on bone repair. In experiments with HA granulate, bone regenerate replaced up to one half of the area of defect by day 90. After insertion of a mixture of granulate and HA powder in bone defects the newly formed bone occupied a little more than one-third of the defect area. In experiments with HA powder suspension the size of bone defect by day 90 was the same as after healing under a blood clot.
在实验大鼠中，研究了在股骨中填充各种形式的羟基磷灰石（HA）后诱导缺损的愈合时间进程，观察时间为造成缺损后的第30天、60天和90天。HA颗粒对骨修复的效果最佳。在使用HA颗粒的实验中，到第90天时，骨再生组织替代了缺损面积的一半。在骨缺损中植入颗粒与HA粉末的混合物后，新形成的骨占据了略多于缺损面积三分之一的区域。在使用HA粉末悬液的实验中，到第90天时骨缺损的大小与在血凝块下愈合后的大小相同。
