Grigor'ian A S, Volozhin A I, al-Akhmar N, Titov M N
Stomatologiia (Mosk). 1998;77(4):9-13.
Tissue status at the site of experimental bone defects filled by two compositions based on polyacrylamide gel and hydroxyapatite with (experimental group) and without (controls) lysozyme was studied in rats by the histomorphological method. "Negative" symptoms, such as inflammation, formation of osteocyte-free bone at the interface of the defect, and reduction of red bone marrow were more manifest in the controls than in animals treated with lysozyme. In the test group substitution of composite material for connective tissue structures and bone reparation were much more active and rapid than in the controls. Inflammation and dystrophic changes at the interface of defects were less pronounced and gradually resolved.
采用组织形态学方法，在大鼠身上研究了由基于聚丙烯酰胺凝胶和羟基磷灰石的两种组合物填充实验性骨缺损部位的组织状态，其中一种含有溶菌酶（实验组），另一种不含溶菌酶（对照组）。“负面”症状，如炎症、缺损界面处无骨细胞骨的形成以及红骨髓减少，在对照组中比在用溶菌酶治疗的动物中更为明显。在测试组中，复合材料替代结缔组织结构和骨修复比对照组更为活跃和迅速。缺损界面处的炎症和营养不良性变化不那么明显，并逐渐消退。
