Berghella A M, Pellegrini P, Contasta I, Del Beato T, Adorno D
Istituto CNR di Tipizzazione Tissutale eProblemi della Dialisi-L'Aquila, Italia.
Cancer Biother Radiopharm. 1998 Aug;13(4):225-37. doi: 10.1089/cbr.1998.13.225.
The theory that an imbalance in the control of the cell cycle contributes to the appearance and progression of neoplastic disease is gaining more ground all the time. This new line of research into tumor disease is a result of the progress made in the comprehension of cell death (apoptosis) and the discovery of alterations in the apoptotic pathway in patients with cancer, which have also been correlated to disease mechanisms. Alterations in the cycle of events that brings about apoptosis can result in tumor cells resistant to chemotherapy. In fact one of the inherent risks of chemotherapy is the generation of new, more aggressive, clonal variants and destruction of healthy cells with deleterious effects on the organism. This review examines the results of studies concerning the identification of the alterations in apoptotic mechanisms in carcinogenesis and the mechanisms governing their regulation. The aim was to evaluate if such data could be of use in identifying drugs able to improve cancer treatment.
细胞周期控制失衡导致肿瘤性疾病的出现和进展这一理论正日益得到认可。肿瘤疾病这一全新研究方向是在细胞死亡（凋亡）理解方面取得进展以及发现癌症患者凋亡途径改变的结果，这些改变也与疾病机制相关。导致凋亡的事件周期发生改变会使肿瘤细胞对化疗产生抗性。事实上，化疗的一个固有风险是产生新的、更具侵袭性的克隆变体以及破坏健康细胞，对机体产生有害影响。本综述考察了有关确定致癌过程中凋亡机制改变及其调控机制的研究结果。目的是评估此类数据是否有助于识别能够改善癌症治疗的药物。
