磷信号转导作为大肠杆菌弧双组分系统信号传递的唯一生理途径。
Phosphorelay as the sole physiological route of signal transmission by the arc two-component system of Escherichia coli.
作者信息
Kwon O, Georgellis D, Lin E C
机构信息
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
出版信息
J Bacteriol. 2000 Jul;182(13):3858-62. doi: 10.1128/JB.182.13.3858-3862.2000.
Abstract
The Arc two-component system, comprising a tripartite sensor kinase (ArcB) and a response regulator (ArcA), modulates the expression of numerous genes involved in respiratory functions. In this study, the steps of phosphoryl group transfer from phosphorylated ArcB to ArcA were examined in vivo by using single copies of wild-type and mutant arcB alleles. The results indicate that the signal transmission occurs solely by His-Asp-His-Asp phosphorelay.
摘要
Arc双组分系统由一个三联体传感器激酶（ArcB）和一个反应调节因子（ArcA）组成，可调节许多参与呼吸功能的基因的表达。在本研究中，通过使用野生型和突变型arcB等位基因的单拷贝，在体内检测了磷酸基团从磷酸化的ArcB转移到ArcA的步骤。结果表明，信号传递仅通过组氨酸-天冬氨酸-组氨酸-天冬氨酸磷酸中继发生。
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