Hirano T, Ishihara K, Hibi M
Division of Molecular Oncology C-7, Biomedical Research Center, Osaka University Graduate School of Medicine, 2-2 Yamada-oko, Suita, Osaka 565-0871, Japan.
Oncogene. 2000 May 15;19(21):2548-56. doi: 10.1038/sj.onc.1203551.
Members of the IL-6 cytokine family are involved in a variety of biological responses, including the immune response, inflammation, hematopoiesis, and oncogenesis by regulating cell growth, survival, and differentiation. These cytokines use gp130 as a common receptor subunit. The binding of ligand to gp130 activates the JAK/STAT signal transduction pathway, where STAT3 plays a central role in transmitting the signals from the membrane to the nucleus. STAT3 is essential for gp130-mediated cell survival and G1 to S cell-cycle-transition signals. Both c-myc and pim have been identified as target genes of STAT3 and together can compensate for STAT3 in cell survival and cell-cycle transition. STAT3 is also required for gp130-mediated maintenance of the pluripotential state of proliferating embryonic stem cells and for the gp130-induced macrophage differentiation of M1 cells. Furthermore, STAT3 regulates cell movement, such as leukocyte, epidermal cell, and keratinocyte migration. STAT3 also appears to regulate B cell differentiation into antibody-forming plasma cells. Since the IL-6/gp130/STAT3 signaling pathway is involved in both B cell growth and differentiation into plasma cells it is likely to play a central role in the generation of plasma cell neoplasias. Oncogene (2000).
白细胞介素-6细胞因子家族的成员通过调节细胞生长、存活和分化参与多种生物学反应，包括免疫反应、炎症、造血作用和肿瘤发生。这些细胞因子将gp130用作共同的受体亚基。配体与gp130的结合激活JAK/STAT信号转导通路，其中STAT3在将信号从细胞膜传递到细胞核中起核心作用。STAT3对于gp130介导的细胞存活以及从G1期到S期的细胞周期转换信号至关重要。c-myc和pim均已被确定为STAT3的靶基因，二者共同作用可在细胞存活和细胞周期转换中补偿STAT3。STAT3对于gp130介导的增殖胚胎干细胞多能状态的维持以及gp130诱导的M1细胞向巨噬细胞的分化也是必需的。此外，STAT3调节细胞运动，如白细胞、表皮细胞和角质形成细胞的迁移。STAT3似乎还调节B细胞分化为产生抗体的浆细胞。由于白细胞介素-6/gp130/STAT3信号通路参与B细胞生长以及向浆细胞的分化，因此它可能在浆细胞肿瘤的发生中起核心作用。《癌基因》（2000年）
