荷马：神经活动与谷氨酸受体功能之间的一种联系。
Homer: a link between neural activity and glutamate receptor function.
作者信息
Xiao B, Tu J C, Worley P F
机构信息
Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
出版信息
Curr Opin Neurobiol. 2000 Jun;10(3):370-4. doi: 10.1016/s0959-4388(00)00087-8.
Abstract
The proteins of the Homer family bind to proline-rich sequences in group I metabotropic glutamate receptors, inositol trisphosphate receptors, ryanodine receptors, and Shank family proteins. Homer proteins also self associate and function as adaptors to couple interacting proteins. Recent observations indicate a role for Homer complexes in signal transduction, synaptogenesis and receptor trafficking.
摘要
荷马家族的蛋白质与I型代谢型谷氨酸受体、肌醇三磷酸受体、兰尼碱受体和Shank家族蛋白质中富含脯氨酸的序列结合。荷马蛋白也能自我结合，并作为衔接蛋白来连接相互作用的蛋白质。最近的观察结果表明，荷马复合体在信号转导、突触形成和受体运输中发挥作用。
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