Detorakis E T, Drakonaki E E, Spandidos D A
Medical School, University of Crete, Heraklion 71110, Crete, Greece.
Int J Mol Med. 2000 Jul;6(1):35-41.
Pterygium is a lesion of the corneoscleral limbus which tends to grow in size, often recurs after surgical excision and is associated with exposure to solar light. Additionally, a family history is frequently reported. Loss of heterozygosity (LOH), increased P53 expression and the presence of oncogenic viruses, such as human papilloma virus (HPV) and herpes simplex virus (HSV), have been detected in pterygia, supporting the possible neoplastic nature of the lesion. Co-infection by HSV and HPV as well as LOH at some loci have also been correlated with clinical features, such as postoperative recurrence and history of conjunctivitis. A possible model of pterygium formation is proposed, in which genetic predisposition, environmental factors and viral infection(s) participate in a multi-step process. Future research may lead to new ways of pterygium treatment such as anti-viral or gene therapy.
翼状胬肉是一种角巩膜缘病变，其大小往往会增大，手术切除后常复发，且与日光暴露有关。此外，常有家族病史报告。在翼状胬肉中已检测到杂合性缺失（LOH）、P53表达增加以及致癌病毒的存在，如人乳头瘤病毒（HPV）和单纯疱疹病毒（HSV），这支持了该病变可能具有肿瘤性质。HSV和HPV的共同感染以及某些位点的LOH也与临床特征相关，如术后复发和结膜炎病史。提出了一种可能的翼状胬肉形成模型，其中遗传易感性、环境因素和病毒感染参与了一个多步骤过程。未来的研究可能会带来翼状胬肉治疗的新方法，如抗病毒或基因治疗。
