Raina Usha K, Pavitra Banu, Bhattacharya Shruti, Ravinesh Kumar, Goel Ruchi
Department of Ophthalmology, Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi, India.
Oman J Ophthalmol. 2023 Feb 21;16(1):30-34. doi: 10.4103/ojo.ojo_56_22. eCollection 2023 Jan-Apr.
Pterygium is very common in India and is usually removed by limbal conjunctival autograft transplantation (LCAT), which, despite being the first-line therapy, is still associated with recurrences of up to 18%.
To compare the safety and efficacy of topical cyclosporine A (CsA) and interferon (IFN) alpha-2b in the prevention of postoperative recurrence of pterygium.
A total of 40 patients with primary pterygium were randomized into two equal groups, Group C and Group I. Both the groups underwent LCAT, with Group C kept on topical cyclosporine 0.05% (CsA) 4 times daily and Group I on topical IFN alpha 2b 0.2 million IU 4 times daily postoperatively for 3 months. Pre- and posttreatment best-corrected visual acuity (BCVA), recurrence, and complications were assessed at day 1, week 1, 1 month, and 3 months.
The mean preoperative BCVA of 0.51 ± 0.18 and 0.51 ± 0.23 improved to 0.13 ± 0.13 and 0.13 ± 0.13 in Group C and Group I, respectively, after 3 months of treatment ( < 0.0001). Recurrence was seen in 2 cases in Group C and in 1 case in Group I at 3 months. No significant complications occurred in either of the groups.
Topical CsA and IFN Alpha-2b are newer efficacious adjuvants with LCAT for prevention of postoperative pterygium recurrence.
翼状胬肉在印度非常常见，通常通过角膜缘结膜自体移植术（LCAT）切除，尽管这是一线治疗方法，但复发率仍高达18%。
比较局部应用环孢素A（CsA）和干扰素（IFN）α-2b预防翼状胬肉术后复发的安全性和有效性。
将40例原发性翼状胬肉患者随机分为两组，C组和I组。两组均接受LCAT，C组术后每天4次局部应用0.05%环孢素（CsA），I组术后每天4次局部应用0.2万国际单位干扰素α-2b，持续3个月。在第1天、第1周、1个月和3个月时评估治疗前后的最佳矫正视力（BCVA）、复发情况和并发症。
治疗3个月后，C组和I组的术前平均BCVA分别从0.51±0.18和0.51±0.23提高到0.13±0.13和0.13±0.13（P<0.0001）。3个月时，C组有2例复发，I组有1例复发。两组均未发生明显并发症。
局部应用CsA和干扰素α-2b是与LCAT联合使用预防翼状胬肉术后复发的新型有效辅助药物。
