Dixon M F, Cowen D M, Cooper E H
Biomedicine. 1975 Sep 10;23(7):247-52.
The long term administration of dimethylhydrazine to mice induces severe hepatotoxic damage. Parenchymal cell pleomorphism and necrosis were later associated with reticulin collapse and bile duct proliferation. Withdrawing the drug after 17 weeks was followed by some improvement in the parenchymal cells but there was a chronic proliferative response tending towards early cirrhotic changes. The rats appeared relatively resistant to the hepatotoxic effects but unlike the mice the colon tumors arising in these animals bled frequently and could result in profound anemia.
长期给小鼠注射二甲基肼会导致严重的肝毒性损伤。实质细胞多形性和坏死随后与网状纤维塌陷及胆管增生相关。在17周后停药，实质细胞有一定程度的改善，但出现了慢性增殖反应，有趋向早期肝硬化改变的趋势。大鼠对肝毒性作用表现出相对抗性，但与小鼠不同的是，这些动物发生的结肠肿瘤经常出血，可导致严重贫血。
