[妊娠相关变化对1,2 - 二甲基肼诱导大鼠致癌作用的修饰效应]
[Modifying effects of changes connected with pregnancy on 1,2-dimethylhydrazine-induced carcinogenesis in rats].
作者信息
Napalkov N P, Mikheev A M, Blinova G A
出版信息
Eksp Onkol. 1990;12(6):37-40.
The modifying effect of pregnancy and lactation on carcinogenesis induced by single injection of 1,2-dimethylhydrazine to female rats 30 days before mating has been studied. The total incidence of malignant tumours in rats with pseudopregnancy, single pregnancy, pregnancy and lactation, repeated pregnancies was lower in comparison with virgin animals (75, 44, 68, 59 and 93%, respectively). Colon adenocarcinoma incidence in rats with single pregnancy or repeated pregnancies was lower than that in virgin rats (42, 49 and 76%, respectively). Protective effect was observed mainly in descending colon. The mesenchymal kidney tumours were not developed at all in rats with single pregnancy. In virgin animals it was 31%. The inhibition of tumour incidence in the liver (cholangioma, cholangiocellular carcinoma) was observed in rats with single pregnancy or pregnancy and lactation in comparison with virgin control (3, 5 and 24%, respectively).
研究了妊娠和哺乳期对在交配前30天给雌性大鼠单次注射1,2 - 二甲基肼诱导的致癌作用的影响。假孕、单次妊娠、妊娠并哺乳、多次妊娠大鼠的恶性肿瘤总发生率与未生育动物相比更低（分别为75%、44%、68%、59%和93%）。单次妊娠或多次妊娠大鼠的结肠腺癌发生率低于未生育大鼠（分别为42%、49%和76%）。主要在降结肠观察到保护作用。单次妊娠大鼠完全未发生间质性肾肿瘤。未生育动物中该肿瘤发生率为31%。与未生育对照组相比，单次妊娠或妊娠并哺乳大鼠的肝脏肿瘤（胆管瘤、胆管细胞癌）发生率受到抑制（分别为3%、5%和24%）。
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