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[患有劳斯氏白血病的BALB/C小鼠体液免疫的一个特点]

[A peculiarity in the humoral immunity of BALB/C mice with Rauscher leukemia].

作者信息

Sokolov P P, Bergol'ts V M

出版信息

Biull Eksp Biol Med. 1976 Mar;81(3):356-8.

PMID:1085178
Abstract

There proved to be an increase in B-lymphocyte count (associated with increased synthesis of nonspecific immunoglobulins) in BALB/C mice highly sensitive to Rausher virus, after the administration of a relatively low dose of the virus. After the administration of the virus in combination with complete Freund's adjuvant in the spleen of mice, at the early periods of development of the disease, there were present normal cells synthesizing antibodies against the surface antigen of Rausher leukemia and leukemic cells with blocking antibodies adsorbed on their surface.

摘要

在给对劳舍尔病毒高度敏感的BALB/C小鼠注射相对低剂量的该病毒后,发现其B淋巴细胞计数增加(与非特异性免疫球蛋白合成增加相关)。在小鼠脾脏中同时注射该病毒和完全弗氏佐剂后,在疾病发展的早期阶段,存在合成针对劳舍尔白血病表面抗原抗体的正常细胞以及表面吸附有阻断抗体的白血病细胞。

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