Shalumashvili M A, Sigidin Ia A
Biull Eksp Biol Med. 1976 Jul;82(7):879-81.
Chloroquine added to human lymphocyte culture at the G1 stage had no influcence on the chromosome aberration level in the concentration of 15 mug/ml and suppressed the mitotic activity of the cells almost completely in the concentration of 60 and 100 mug/ml. At the G2 stage chloroquine in the concentration of 15 mug/ml had no cytogenetic effect and in the concentration of 100 mug/ml -- it increased the number of chromosome aberrations significantly.
在G1期添加到人类淋巴细胞培养物中的氯喹，在浓度为15微克/毫升时对染色体畸变水平没有影响，而在浓度为60和100微克/毫升时几乎完全抑制了细胞的有丝分裂活性。在G2期，浓度为15微克/毫升的氯喹没有细胞遗传学效应，而在浓度为100微克/毫升时——它显著增加了染色体畸变的数量。
