Lehman R M, Micheli-Tzanakou E, Zheng J, Hamilton J L
Division of Neurosurgery, UMDNJ-Robert Wood Johnson Medical, New Brunswick, NJ 08901-1977, USA.
Stereotact Funct Neurosurg. 1999;72(2-4):185-91. doi: 10.1159/000029724.
A quantitative on-line analysis of electrical activity in the pallidum of Parkinsonian patients has been developed to determine the focal point of lesioning. A 3D volume image system has been developed to display basal ganglia anatomy and coregister the electrophysiological data within the globus pallidus. Thirty patients undergoing 41 pallidotomies are presented. Neuronal activity from the pallidum is recorded using a semi-microelectrode. Based on this activity, lesioning is performed. Postlesion recordings are made to determine the necessity of additional lesioning. A stereoscopic 3D volume MR image system has been developed that along with on-line signal processing allows visualization of high neural activity in the pallidum and postlesion residual activity.
已开发出一种对帕金森病患者苍白球电活动进行定量在线分析的方法，以确定损伤的焦点。已开发出一种三维体积图像系统，用于显示基底神经节的解剖结构，并将苍白球内的电生理数据进行配准。介绍了30例接受41次苍白球毁损术的患者。使用半微电极记录苍白球的神经元活动。基于这种活动进行毁损。术后进行记录以确定是否需要额外的毁损。已开发出一种立体三维体积磁共振图像系统，该系统与在线信号处理一起，可实现对苍白球高神经活动和术后残余活动的可视化。
