Oshima M, Awaya Y, Fujii T, Kodomari Y, Kuwabara M
Department of Pulmonary Medicine, Hiroshima Prefectural Hospital.
Arerugi. 2000 May;49(5):412-9.
In this study, a total of 60 patients with acute bronchitis, 71 patients with bronchial asthma and 20 healthy volunteers were serologically and bacteriologically analyzed to investigate whether Chlamydia pneumoniae infection is associated with the onset and the exacerbation with acute bronchitis and bronchial asthma. Antibody titers to Chlamydia pneumoniae were also measured and compared by ELISA method. The antibody-positive rate in the patients with acute bronchitis (88.4%) was significantly higher than that in the patients with bronchial asthma (73.3%) or that in the healthy volunteers (60%). And the levels of the IgA antibody in the patients with acute bronchitis were significantly higher than those in the patients with bronchial asthma or those in the healthy volunteers. The rate of acute C. pneumoniae infection in the patients with acute bronchitis (20%) did not show significantly differences compared with that in the patients with bronchial asthma (15.5%) or that in the healthy volunteers (10%). The cases of acute C. pneumoniae infection had both as a single etiologic agent and as a mixed infection, most often with Streptococcus pneumoniae. Therefore, we demonstrated that the acute C. pneumoniae infection may be associated with the onset and the exacerbation in acute bronchitis and bronchial asthma.
在本研究中，对60例急性支气管炎患者、71例支气管哮喘患者和20名健康志愿者进行了血清学和细菌学分析，以调查肺炎衣原体感染是否与急性支气管炎和支气管哮喘的发病及病情加重有关。还采用酶联免疫吸附测定（ELISA）法检测并比较了肺炎衣原体抗体滴度。急性支气管炎患者的抗体阳性率（88.4%）显著高于支气管哮喘患者（73.3%）或健康志愿者（60%）。并且急性支气管炎患者的IgA抗体水平显著高于支气管哮喘患者或健康志愿者。急性支气管炎患者的肺炎衣原体急性感染率（20%）与支气管哮喘患者（15.5%）或健康志愿者（10%）相比，未显示出显著差异。肺炎衣原体急性感染病例既有作为单一病原体的情况，也有作为混合感染的情况，最常见的是与肺炎链球菌混合感染。因此，我们证明肺炎衣原体急性感染可能与急性支气管炎和支气管哮喘的发病及病情加重有关。
