Nishiyama Y, Yamamoto Y, Fukunaga K, Kiuchi T, Satoh K, Takashima H, Ohkawa M, Tanabe M
Department of Radiology, Kagawa Medical University, Kagawa, Japan.
Eur J Nucl Med. 2000 May;27(5):536-41. doi: 10.1007/s002590050540.
The purpose of this study was to investigate the relationship between technetium-99m hexakis-2-methoxyisobutylisonitrile (99mTc-MIBI) accumulation in tumours and response to radiotherapy in non-small cell lung cancer patients in comparison with the findings obtained using thallium-201 chloride (201Tl). Simultaneous dual single-photon emission tomography (SPET) imaging with 600 MBq 99mTc-MIBI and 111 MBq 201Tl was performed in 31 patients with biopsy- or sputum cytology-proven lung cancer. SPET images were acquired 15 min (early) and 2 h (delayed) after injection, and the early ratio, delayed ratio and retention index were measured. The tumours were classified into two groups on the basis of follow-up computed tomography (CT): responders (at least 50% reduction in tumour size) and non-responders (little or no change in tumour size). The mean (+/-SD) values of early ratio, delayed ratio and retention index using 99mTc-MIBI SPET were 3.0+/-1.1, 2.7+/-1.0 and -9.5+/-12.7, respectively, in responders and 2.4+/-0.7, 2.0+/-0.5 and -18.4+/-9.0, respectively, in non-responders. The corresponding values using 201Tl chloride SPET were 3.7+/-1.0, 4.7+/-1.5 and 24.2+/-22.1 in responders and 3.3+/-1.2, 4.0+/-1.3 and 20.4+/-20.5 in nonresponders. Using 99mTc-MIBI, the delayed ratio and retention index in responders were significantly higher than those in non-responders (P<0.01 and P<0.05, respectively). The results of this study indicate that patients with higher delayed ratio and retention index values using 99mTc-MIBI SPET are likely to respond better to radiotherapy than those with lower values. 99mTc-MIBI SPET may give an indication of the short-term response to radiotherapy in patients with non-small cell lung cancer.
本研究的目的是调查非小细胞肺癌患者中，锝-99m 六甲基异丁基异腈（99mTc-MIBI）在肿瘤中的蓄积与放疗反应之间的关系，并与使用氯化铊（201Tl）所获得的结果进行比较。对31例经活检或痰细胞学证实为肺癌的患者，同时进行了600MBq 99mTc-MIBI和111MBq 201Tl的双单光子发射断层扫描（SPET）成像。在注射后15分钟（早期）和2小时（延迟期）采集SPET图像，并测量早期比值、延迟比值和滞留指数。根据随访计算机断层扫描（CT）将肿瘤分为两组：反应者（肿瘤大小至少减少50%）和无反应者（肿瘤大小几乎无变化或无变化）。使用99mTc-MIBI SPET时，反应者的早期比值、延迟比值和滞留指数的平均值（±标准差）分别为3.0±1.1、2.7±1.0和-9.5±12.7，无反应者分别为2.4±0.7、2.0±0.5和-18.4±9.0。使用氯化201Tl SPET时，反应者的相应值分别为3.7±1.0、4.7±1.5和24.2±22.1，无反应者分别为3.3±1.2、4.0±1.3和20.4±20.5。使用99mTc-MIBI时，反应者的延迟比值和滞留指数显著高于无反应者（分别为P<0.01和P<0.05）。本研究结果表明，使用99mTc-MIBI SPET时延迟比值和滞留指数值较高的患者，可能比值较低的患者对放疗反应更好。99mTc-MIBI SPET可能提示非小细胞肺癌患者对放疗的短期反应。
