Yamamoto Y, Kawasaki Y, Nishiyama Y, Fukunaga K, Satoh K, Takashima H, Ohkawa M, Kumazawa Y, Fujita J, Tanabe M
Department of Radiology, Kagawa Medical School.
Kaku Igaku. 1996 May;33(5):501-11.
We performed comparative study, using 99mTc-MIBI and 201Tl-chloride in patients with primary lung cancer. There were 42 patients with primary lung cancer. All patients underwent dual radionuclide imaging with 201Tl-chloride and 99mTc-MIBI. Regions of interest were placed over the tumor area (T) and contralateral normal lung area (N). A tumor to normal lung ratio (T/N ratio) and retention index were calculated by early and delayed ratios. In the SPECT images, the positive rate was 98% in both the early and delayed images for 201Tl-chloride and 95% in the early and 88% in the delayed images for 99mTc-MIBI. Both early and delayed T/N ratios of 201Tl-chloride were significantly higher than those of 99mTc-MIBI. The retention index of 201Tl-chloride was higher than that of 99mTc-MIBI. T/N ratio and retention index did not significantly correlated with reference to histological types. We conclude that 99mTc-MIBI SPECT can be helpful in localizing primary lung cancers. However, in our study the tumor accumulation of 99mTc-MIBI was significantly lower compared with 201Tl-chloride.
我们对原发性肺癌患者使用99mTc-MIBI和201Tl-氯化物进行了对比研究。共有42例原发性肺癌患者。所有患者均接受了201Tl-氯化物和99mTc-MIBI双放射性核素显像。在肿瘤区域（T）和对侧正常肺区域（N）设置感兴趣区。通过早期和延迟比值计算肿瘤与正常肺比值（T/N比值）和滞留指数。在SPECT图像中，201Tl-氯化物早期和延迟图像的阳性率均为98%，99mTc-MIBI早期图像阳性率为95%，延迟图像阳性率为88%。201Tl-氯化物的早期和延迟T/N比值均显著高于99mTc-MIBI。201Tl-氯化物的滞留指数高于99mTc-MIBI。T/N比值和滞留指数与组织学类型无显著相关性。我们得出结论，99mTc-MIBI SPECT有助于原发性肺癌的定位。然而，在我们的研究中，99mTc-MIBI的肿瘤摄取与201Tl-氯化物相比显著较低。
