Kameda K, Kusumi I, Suzuki K, Miura J, Sasaki Y, Koyama T
Department of Psychiatry, Hokkaido University School of Medicine, Sapporo, Japan.
J Mol Neurosci. 2000 Feb-Apr;14(1-2):77-86. doi: 10.1385/JMN:14:1-2:077.
Effects of citalopram on dopamine D2 receptor expression in the rat brain striatum were studied. Repeated administration of citalopram increased the amount of dopamine D2 receptors, the level of dopamine D2 receptor mRNA, and the transcription rate of the dopamine D2 receptor gene. Single administration of citalopram also increased the level of dopamine D2 receptor mRNA with a maximum effect in 2-4 h after the treatment, and the transcription rate of the dopamine D2 receptor gene. The administration of 5-hydroxytryptophan (5-HTP) also increased the level of dopamine D2 receptor mRNA. These results suggest that the increase in the dopamine D2 receptor expression induced by citalopram may be owing, at least partially, to the stimulation of the dopamine D2 receptor gene transcription, and that serotonin (5-HT) may mediate the effects of citalopram in the induction of dopamine D2 receptor expression.
研究了西酞普兰对大鼠脑纹状体中多巴胺D2受体表达的影响。重复给予西酞普兰可增加多巴胺D2受体的数量、多巴胺D2受体mRNA的水平以及多巴胺D2受体基因的转录速率。单次给予西酞普兰也可增加多巴胺D2受体mRNA的水平，在治疗后2 - 4小时达到最大效应，同时增加多巴胺D2受体基因的转录速率。给予5 - 羟色氨酸（5 - HTP）也可增加多巴胺D2受体mRNA的水平。这些结果表明，西酞普兰诱导的多巴胺D2受体表达增加可能至少部分归因于多巴胺D2受体基因转录的刺激，并且血清素（5 - HT）可能介导西酞普兰在诱导多巴胺D2受体表达中的作用。
