Rebell G, Forster R K
Sabouraudia. 1976 Jul;14(2):155-70. doi: 10.1080/00362177685190231.
Four cases of human keratitis caused by the tropical fungus Lasiodiplodia theobromae have been encountered in Miami, Florida bringing to 8 the number of cases reported in the world literature. Two of the ulcers were mild. Three patients recovered without severe impairment of vision after topical polyene treatment, but 1 patient with a severe ulcer required therapeutic keratoplasty after 11 days of topical natamycin. Histopathology revealed fungus deep in the cornea, invading Descemet's membrane. L. theobromae appeared to have collagenase activity in vitro. Inoculation of L. theobromae into the corneas of rabbits produced progressive ulcers. The fungus was endemic in Miami on home grown and imported bananas. Polyene antimycotic antibiotics were fungicidal for L. theobromae in vitro. Thiabendazole was effectively fungistatic but varied in fungicidal effect. Clotrimazole and miconazole were only incompletely fungistatic. Of 7 strains of L. theobromae tested, 4 were relatively resistant to 5-flurocytosine.
在佛罗里达州迈阿密发现了4例由热带真菌可可毛色二孢引起的人类角膜炎病例，这使得世界文献报道的病例数增至8例。其中两例溃疡较轻。3例患者经局部使用多烯类药物治疗后视力未严重受损而康复，但1例患有严重溃疡的患者在局部使用那他霉素11天后需要进行治疗性角膜移植。组织病理学显示真菌深入角膜，侵犯后弹力层。可可毛色二孢在体外似乎具有胶原酶活性。将可可毛色二孢接种到兔角膜中会产生进行性溃疡。这种真菌在迈阿密本地种植和进口的香蕉上呈地方性流行。多烯类抗真菌抗生素在体外对可可毛色二孢具有杀菌作用。噻苯达唑具有有效的抑菌作用，但杀菌效果有所不同。克霉唑和咪康唑仅具有不完全的抑菌作用。在测试的7株可可毛色二孢菌株中，4株对5-氟胞嘧啶相对耐药。
