Rantanen T, Penninx B W, Masaki K, Lintunen T, Foley D, Guralnik J M
Epidemiology, Demography and Biometry Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.
J Am Geriatr Soc. 2000 Jun;48(6):613-7. doi: 10.1111/j.1532-5415.2000.tb04717.x.
To study depressed mood as a predictor of strength decline within body weight categories over a 3-year follow-up period.
A prospective cohort study over 3 years.
Honolulu, Hawaii.
The subjects were 2275 men participating in the Honolulu Heart Program with an average age of 77.1 years (range 71-92 years), who were not cognitively impaired at baseline (Exam 4), and who participated in maximal hand grip strength measurements at baseline and 3 years later (Exam 5).
Hand grip strength was measured using a dynamometer. Depressive symptoms were studied using an 11-item version of Center for Epidemiologic Studies Depression Scale with 9 as a cutoff. Body weight categories were formed on the basis of body mass index (BMI) (BMI = weight/height2; underweight: BMI < 20; normal weight: BMI 20-24.99, overweight: BMI > or = 25).
At baseline, 9.4% of the participants were rated as having depressed mood. The mean individual strength change over 3 years was - 6.9% (standard deviation 14.0). Steep strength decline was determined as losing > or = 14% (lowest quartile). The proportions of those with steep strength decline in the groups based on combined distributions of BMI and depressed mood were: underweight/ depressed (n = 22) 41%, underweight/not depressed (n = 200) 28%, normal weight/depressed (n = 127) 30%, normal weight/not depressed (n = 1181) 25%, overweight/depressed (n = 55) 31%, overweight/not depressed (n = 675, referent) 21%. After adjusting for baseline strength, age, height, sociodemographic variables and diseases, the odds ratio for steep strength decline was more than four times greater among those who were depressed and underweight, and twice as great among people who were depressed and normal weight compared with those who were nondepressed and overweight. The risks of nondepressed under- and normal weight people and depressed overweight people did not differ from the reference group.
Depressed mood was associated with increased risk of steep strength decline, in particular in older men with low body weight. Low body weight in combination with depressed mood may be an indicator of frailty or severe disease status that leads to accelerated strength loss and disability.
研究在3年随访期内，抑郁情绪作为体重类别中力量下降预测指标的情况。
一项为期3年的前瞻性队列研究。
夏威夷檀香山。
2275名男性参与了檀香山心脏项目，平均年龄77.1岁（范围71 - 92岁），他们在基线时（第4次检查）无认知障碍，并在基线和3年后（第5次检查）参与了最大握力测量。
使用测力计测量握力。使用流行病学研究中心抑郁量表的11项版本研究抑郁症状，以9分为临界值。根据体重指数（BMI）（BMI = 体重/身高²；体重过轻：BMI < 20；正常体重：BMI 20 - 24.99，超重：BMI ≥ 25）划分体重类别。
在基线时，9.4%的参与者被评定为有抑郁情绪。3年期间个体力量的平均变化为 - 6.9%（标准差14.0）。力量急剧下降被定义为下降≥14%（最低四分位数）。根据BMI和抑郁情绪的综合分布分组，力量急剧下降者的比例分别为：体重过轻/抑郁（n = 22）41%，体重过轻/未抑郁（n = 200）28%，正常体重/抑郁（n = 127）30%，正常体重/未抑郁（n = 1181）25%，超重/抑郁（n = 55）31%，超重/未抑郁（n = 675，参照组）21%。在对基线力量、年龄、身高、社会人口统计学变量和疾病进行调整后，与未抑郁且超重者相比，抑郁且体重过轻者力量急剧下降的比值比高出四倍多，抑郁且正常体重者高出两倍。未抑郁的体重过轻和正常体重者以及抑郁的超重者的风险与参照组无差异。
抑郁情绪与力量急剧下降风险增加相关，尤其是在体重低的老年男性中。体重低与抑郁情绪相结合可能是虚弱或严重疾病状态的一个指标，会导致力量加速丧失和残疾。
