Fujita H, Iida H, Ido K, Matsuda Y, Oka M, Nakamura T
Department of Orthopaedic Surgery, Faculty of Medicine, Kyoto University, Japan.
J Bone Joint Surg Br. 2000 May;82(4):614-8. doi: 10.1302/0301-620x.82b4.9739.
We evaluated the efficacy and biocompatibility of porous apatite-wollastonite glass ceramic (AW-GC) as an intramedullary plug in total hip replacement (THR) for up to two years in 22 adult beagle dogs. Cylindrical porous AW-GC rods (70% porosity, mean pore size 200 microm) were prepared. Four dogs were killed at 1, 3, 6 and 12 months each and six at 24 months after implantation. Radiological evaluation confirmed the efficacy of porous AW-CG as an intramedullary plug. Histological evaluation showed osteoconduction at one month and resorption of the porous AW-GC, which was replaced by newly-formed bone, at 24 months. Our findings indicate that porous AW-GC can be used clinically as an intramedullary plug in THR.
我们在22只成年比格犬身上评估了多孔磷灰石-硅灰石玻璃陶瓷（AW-GC）作为全髋关节置换术（THR）中髓内塞的疗效和生物相容性，随访长达两年。制备了圆柱形多孔AW-GC棒（孔隙率70%，平均孔径200微米）。分别在植入后1、3、6和12个月处死4只犬，在24个月处死6只犬。放射学评估证实了多孔AW-CG作为髓内塞的疗效。组织学评估显示，植入1个月时具有骨传导性，24个月时多孔AW-GC发生吸收，并被新形成的骨替代。我们的研究结果表明，多孔AW-GC可在临床上用作THR的髓内塞。
