Gardner D K, Lane M, Stevens J, Schlenker T, Schoolcraft W B
Colorado Center for Reproductive Medicine, Englewood, Colorado, USA.
Fertil Steril. 2000 Jun;73(6):1155-8. doi: 10.1016/s0015-0282(00)00518-5.
To determine the relationship between blastocyst score and pregnancy outcome.
Retrospective review of blastocyst transfer in an IVF clinic.
Private assisted reproductive technology unit.
PATIENT(S): 107 patients undergoing blastocyst culture and transfer of two embryos.
INTERVENTION(S): Culture of all pronucleate embryos in sequential media to the blastocyst stage (day 5), followed by transfer of two blastocysts.
MAIN OUTCOME MEASURE(S): Implantation rates, pregnancy rates, and twinning were analyzed.
RESULT(S): When a patient received two top-scoring blastocysts (64% of patients), implantation and pregnancy rates were 70% and 87%, respectively. The twinning rate in this group was 61%. When only one top-quality blastocyst was available for transfer (21% of patients), the implantation and pregnancy rates were 50% and 70%. The twinning rate for this group was 50%. In contrast, when only low-scoring blastocysts were available for transfer (15% of patients), implantation and pregnancy rates were 28% and 44%, and the twinning rate was 29%. No monozygotic twins were observed in this group of patients.
CONCLUSION(S): The ability to transfer one high-scoring blastocyst should lead to pregnancy rates greater than 60%, without the complication of twins.
确定囊胚评分与妊娠结局之间的关系。
对一家体外受精诊所的囊胚移植进行回顾性研究。
私立辅助生殖技术单位。
107例接受囊胚培养并移植两个胚胎的患者。
将所有原核胚胎在序贯培养基中培养至囊胚阶段（第5天），然后移植两个囊胚。
分析着床率、妊娠率和双胎妊娠情况。
当患者移植两个高分囊胚时（64%的患者），着床率和妊娠率分别为70%和87%。该组双胎妊娠率为61%。当仅有一个优质囊胚可供移植时（21%的患者），着床率和妊娠率分别为50%和70%。该组双胎妊娠率为50%。相比之下，当仅有低分囊胚可供移植时（15%的患者），着床率和妊娠率分别为28%和44%，双胎妊娠率为29%。该组患者未观察到单卵双胎。
移植一个高分囊胚应能使妊娠率高于60%，且无双胎并发症。
