Gardner David K, Surrey Eric, Minjarez Debra, Leitz Annette, Stevens John, Schoolcraft William B
Colorado Center for Reproductive Medicine, Englewood, Colorado 80110, USA.
Fertil Steril. 2004 Mar;81(3):551-5. doi: 10.1016/j.fertnstert.2003.07.023.
To determine the efficacy of single blastocyst transfer.
Prospective randomized trial.
Private assisted reproductive technology unit.
PATIENT(S): Forty-eight women undergoing IVF-embryo transfer with day 3 FSH <or=10 mIU/mL and at least 10 follicles >12 mm in diameter on day of hCG administration.
INTERVENTION(S): Embryo culture to the blastocyst stage in sequential media G1/G2 followed by transfer of either one or two blastocysts.
MAIN OUTCOME MEASURE(S): Implantation rate, ongoing pregnancy rate, and twinning.
RESULT(S): The transfer of a single blastocyst resulted in an implantation and ongoing pregnancy rate of 60.9% with no twins. The transfer of two blastocysts resulted in an implantation rate of 56%, an ongoing pregnancy rate of 76% with a 47.4% incidence of twins.
CONCLUSION(S): Single blastocyst transfer is an effective method of eliminating multiple births while maintaining high pregnancy rates in this selected group of patients.
确定单囊胚移植的有效性。
前瞻性随机试验。
私立辅助生殖技术机构。
48名接受体外受精 - 胚胎移植的女性，其在注射人绒毛膜促性腺激素（hCG）当天的促卵泡生成素（FSH）水平≤10 mIU/mL，且至少有10个直径>12 mm的卵泡。
在序贯培养基G1/G2中将胚胎培养至囊胚阶段，然后移植一个或两个囊胚。
着床率、持续妊娠率和双胎情况。
单囊胚移植的着床率和持续妊娠率为60.9%，无双胎。两个囊胚移植的着床率为56%，持续妊娠率为76%，双胎发生率为47.4%。
在这一特定患者群体中，单囊胚移植是一种在保持高妊娠率的同时消除多胎妊娠的有效方法。
