人类对氧磷酶（PON1）基因上游的多态性及其与PON1表达的关联。

A polymorphism upstream from the human paraoxonase (PON1) gene and its association with PON1 expression.

作者信息

Suehiro T, Nakamura T, Inoue M, Shiinoki T, Ikeda Y, Kumon Y, Shindo M, Tanaka H, Hashimoto K

机构信息

The Second Department of Internal Medicine, Kochi Medical School, Kohasu, Okoh-cho, Nankoku, 781-8505, Kochi, Japan.

出版信息

Atherosclerosis. 2000 Jun;150(2):295-8. doi: 10.1016/s0021-9150(99)00379-2.

DOI:10.1016/s0021-9150(99)00379-2

PMID:10856521

Abstract

Human serum paraoxonase (PON1) is an esterase that has been shown to decrease the susceptibility of lipoproteins to lipid peroxidation. We found a polymorphism of cytosine/thymidine (-108C/T, the number is from the ATG codon) in the upstream region of the PON1 gene. The luciferase activity was lower in the -108T allele than in the -108C allele. The serum PON1 concentrations in 132 normal subjects were as follows: -108CC>-108CT and>-108TT genotypes. The polymorphism upstream from the PON1 gene is associated with transcription of the PON1 gene and the serum PON1 concentration.

摘要

人血清对氧磷酶（PON1）是一种酯酶，已被证明可降低脂蛋白对脂质过氧化的易感性。我们在PON1基因上游区域发现了一个胞嘧啶/胸腺嘧啶多态性（-108C/T，编号从ATG密码子起）。-108T等位基因的荧光素酶活性低于-108C等位基因。132名正常受试者的血清PON1浓度如下：-108CC基因型>-108CT基因型>-108TT基因型。PON1基因上游的多态性与PON1基因的转录及血清PON1浓度相关。