癌症与对氧磷酶1之间的关系
The Relationship between Cancer and Paraoxonase 1.
作者信息
Medina-Díaz Irma Martha, Ponce-Ruíz Néstor, Rojas-García Aurora Elizabeth, Zambrano-Zargoza José Francisco, Bernal-Hernández Yael Y, González-Arias Cyndia Azucena, Barrón-Vivanco Briscia S, Herrera-Moreno José Francisco
机构信息
Laboratorio de Contaminación y Toxicología Ambiental, Secretaría de Investigación y Posgrado, Universidad Autónoma de Nayarit, Tepict 63000, Mexico.
Unidad Académica de Ciencias Químico Biológicas y Farmacéuticas, Universidad Autónoma de Nayarit, Tepic 63000, Mexico.
出版信息
Antioxidants (Basel). 2022 Mar 31;11(4):697. doi: 10.3390/antiox11040697.
Extensive research has been carried out to understand and elucidate the mechanisms of paraoxonase 1 (PON1) in the development of diseases including cancer, cardiovascular diseases, neurological diseases, and inflammatory diseases. This review focuses on the relationship between PON1 and cancer. The data suggest that PON1, oxidative stress, chronic inflammation, and cancer are closely linked. Certainly, the gene expression of PON1 will remain challenging to study. Therefore, targeting PON1, redox-sensitive pathways, and transcription factors promise prevention and therapy in the development of several diseases, including cancer.
为了理解和阐明对氧磷酶1（PON1）在包括癌症、心血管疾病、神经疾病和炎症性疾病在内的疾病发展中的作用机制，已经开展了广泛的研究。本综述聚焦于PON1与癌症之间的关系。数据表明，PON1、氧化应激、慢性炎症和癌症紧密相连。当然，研究PON1的基因表达仍将具有挑战性。因此，针对PON1、氧化还原敏感途径和转录因子有望预防和治疗包括癌症在内的多种疾病的发展。
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