Cruz M L, Luna S P, de Castro G B, Massone F, Rosa A L
Department of Veterinary Surgery and Anesthesiology, Faculty of Veterinary Medicine and Animal Science, Botucatu, SP, Brazil.
Can Vet J. 2000 Jun;41(6):481-5.
The aim of this study was to investigate the effect of several drug combinations (atropine, xylazine, romifidine, methotrimeprazine, midazolam, or fentanyl) with ketamine for short term anesthesia in cats. Twelve cats were anesthetized 6 times by using a cross-over Latin square protocol: methotrimeprazine was combined with midazolam, ketamine, and fentanyl; midazolam and ketamine; romifidine and ketamine; and xylazine and ketamine. Atropine was combined with romifidine and ketamine, and xylazine and ketamine. Temperature, heart rate, and respiratory rate decreased in all groups. Apnea occurred in 1 cat treated with methotrimeprazine, romifidine, and ketamine, suggesting that ventilatory support may be necessary when this protocol is used. Emesis occurred in some cats treated with alpha 2-adrenoceptor agonists, and this side effect should be considered when these drugs are used.
本研究的目的是调查几种药物组合(阿托品、赛拉嗪、罗米定、甲哌氯丙嗪、咪达唑仑或芬太尼)与氯胺酮联合用于猫短期麻醉的效果。采用交叉拉丁方方案对12只猫进行了6次麻醉:甲哌氯丙嗪与咪达唑仑、氯胺酮和芬太尼联合使用;咪达唑仑和氯胺酮联合使用;罗米定和氯胺酮联合使用;赛拉嗪和氯胺酮联合使用。阿托品与罗米定和氯胺酮联合使用,以及赛拉嗪和氯胺酮联合使用。所有组的体温、心率和呼吸频率均下降。1只接受甲哌氯丙嗪、罗米定和氯胺酮治疗的猫出现了呼吸暂停,这表明使用该方案时可能需要通气支持。一些接受α2-肾上腺素能受体激动剂治疗的猫出现了呕吐,使用这些药物时应考虑到这种副作用。