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褪黑素在弱、静态及极低频(50赫兹)磁场分子机制中的作用

[The role of melatonin in the molecular mechanism of weak, static and extremely low frequency (50 Hz) magnetic fields (ELF)].

作者信息

Jajte J, Zmyślony M

机构信息

Zakładu Zagrozeń Fizycznych, Instytut Medycyny Pracy, Lodzi.

出版信息

Med Pr. 2000;51(1):51-7.

PMID:10857076
Abstract

Melatonin is a neurohormone produced by the pineal gland. It has been recently found that it is also an antioxidant and a free radical scavenger. Melatonin was documented to be a direct trap of hydroxyl and peroxyl radicals. Therefore, this hormone could protect cells, tissues and organs against oxidative (free radicals) damage (DNA, protein, lipids). It has been suggested that noxious effects of ELF exposure (cancer or immunological disturbances) could be due to increased the concentration of free radicals induced by magnetic field. This is also leading to a hypothesis that melatonin suppression (by electromagnetic fields) in humans may increase the probability of mutagenic and carcinogenic risks. The future experiments, in vitro and in vivo, should provide an answer to the question on what is the real role of melatonin in the molecular (free radicals) mechanisms of weak magnetic fields.

摘要

褪黑素是一种由松果体分泌的神经激素。最近发现它也是一种抗氧化剂和自由基清除剂。褪黑素被证明是羟基自由基和过氧自由基的直接捕获剂。因此,这种激素可以保护细胞、组织和器官免受氧化(自由基)损伤(DNA、蛋白质、脂质)。有人提出,极低频电磁场暴露的有害影响(癌症或免疫紊乱)可能是由于磁场诱导的自由基浓度增加所致。这也引发了一种假设,即人体中褪黑素(因电磁场)受到抑制可能会增加诱变和致癌风险。未来的体外和体内实验应该能回答褪黑素在弱磁场分子(自由基)机制中的真正作用是什么这个问题。

相似文献

1
[The role of melatonin in the molecular mechanism of weak, static and extremely low frequency (50 Hz) magnetic fields (ELF)].褪黑素在弱、静态及极低频(50赫兹)磁场分子机制中的作用
Med Pr. 2000;51(1):51-7.
2
Protective effect of melatonin against in vitro iron ions and 7 mT 50 Hz magnetic field-induced DNA damage in rat lymphocytes.褪黑素对体外铁离子和7 mT 50 Hz磁场诱导的大鼠淋巴细胞DNA损伤的保护作用。
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Extremely low frequency electromagnetic fields as effectors of cellular responses in vitro: possible immune cell activation.极低频电磁场作为体外细胞反应的效应物:可能的免疫细胞激活
J Cell Biochem. 2004 Sep 1;93(1):83-92. doi: 10.1002/jcb.20198.
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Interactions of the pineal hormone melatonin with oxygen-centered free radicals: a brief review.松果体激素褪黑素与氧中心自由基的相互作用:简要综述。
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Functional pleiotropy of the neurohormone melatonin: antioxidant protection and neuroendocrine regulation.神经激素褪黑素的功能多效性:抗氧化保护与神经内分泌调节。
Front Neuroendocrinol. 1995 Oct;16(4):383-415. doi: 10.1006/frne.1995.1014.
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Melatonin suppression by static and extremely low frequency electromagnetic fields: relationship to the reported increased incidence of cancer.静态和极低频电磁场对褪黑素的抑制作用:与报道的癌症发病率增加的关系。
Rev Environ Health. 1994 Jul-Dec;10(3-4):171-86. doi: 10.1515/reveh.1994.10.3-4.171.
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Evidence for an effect of ELF electromagnetic fields on human pineal gland function.极低频电磁场对人体松果体功能影响的证据。
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Neuroendocrine mediated effects of electromagnetic-field exposure: possible role of the pineal gland.
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Comparing performances of logistic regression and neural networks for predicting melatonin excretion patterns in the rat exposed to ELF magnetic fields.比较逻辑回归和神经网络在预测暴露于极低频磁场的大鼠褪黑素排泄模式方面的性能。
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The effects of extremely low-frequency magnetic fields on melatonin and cortisol, two marker rhythms of the circadian system.极低频磁场对褪黑素和皮质醇这两种昼夜节律系统标志物节律的影响。
Dialogues Clin Neurosci. 2012 Dec;14(4):381-99. doi: 10.31887/DCNS.2012.14.4/ytouitou.

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Effects of electromagnetic fields exposure on the antioxidant defense system.电磁场暴露对抗氧化防御系统的影响。
J Microsc Ultrastruct. 2017 Oct-Dec;5(4):167-176. doi: 10.1016/j.jmau.2017.07.003. Epub 2017 Aug 2.
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Low dose magnetic fields do not cause oxidative DNA damage in human placental cotyledons in vitro.低剂量磁场不会在体外对人胎盘叶造成氧化性DNA损伤。
Virchows Arch. 2005 Jun;446(6):634-9. doi: 10.1007/s00428-005-1249-8. Epub 2005 Apr 19.