Soler A M, Angell-Petersen E, Warloe T, Tausjø J, Steen H B, Moan J, Giercksky K E
Photodynamic Out-patient Clinic, Norwegian Radium Hospital and Institute for Cancer Research, Oslo, Norway.
Photochem Photobiol. 2000 Jun;71(6):724-9. doi: 10.1562/0031-8655(2000)071<0724:ptosbc>2.0.co;2.
The aim of this prospective randomized study was to compare the clinical and cosmetic outcome of superficial basal cell carcinomas (BCC), using either laser or broadband halogen light, in photodynamic therapy with topical 5-aminolevulinic acid (ALA). A total of 83 patients with 245 superficial BCC were included in the study. Standard treatment involved 15 min of local pretreatment with 99% dimethylsulfoxide (DMSO) before topical application of 20% ALA with DMSO (2%) and ethylendiaminetetraacetic acid (2%) as cofactors for 3 h before light exposure with either laser or a broadband lamp (BL). A complete response was achieved in 95 lesions (86%) in the laser group and 110 lesions (82%) in the BL group 6 months after treatment. Of these, 80 lesions (84%) in the laser group and 101 lesions (92%) in the lamp group were independently evaluated to have an excellent or good cosmetic post-treatment score. No serious adverse events were reported. This study shows that there is no statistical significant difference in cure the rate (P = 0.49) and the cosmetic outcome (P = 0.075) with topical application of a modified ALA-cream between light exposure from a simple BL with continuous spectrum (570-740 nm) or from a red-light laser (monochromatic 630 nm). Cost and safety are further elements in favor of the BL in this setting.
这项前瞻性随机研究的目的是比较在使用外用5-氨基酮戊酸（ALA）进行光动力治疗时，使用激光或宽带卤素光治疗浅表基底细胞癌（BCC）的临床和美容效果。共有83例患者的245个浅表BCC纳入该研究。标准治疗包括在局部外用20% ALA与二甲基亚砜（DMSO，2%）和乙二胺四乙酸（2%）作为辅助因子共3小时之前，先用99%二甲基亚砜进行15分钟的局部预处理，之后用激光或宽带灯（BL）进行光照。治疗6个月后，激光组95个病灶（86%）和BL组110个病灶（82%）实现了完全缓解。其中，激光组80个病灶（84%）和灯组101个病灶（92%）经独立评估治疗后的美容评分优秀或良好。未报告严重不良事件。这项研究表明，使用改良的ALA乳膏外用后，采用具有连续光谱（570 - 740 nm）的简单宽带灯或红光激光（单色630 nm）进行光照，在治愈率（P = 0.49）和美容效果（P = 0.075）方面没有统计学显著差异。在这种情况下，成本和安全性是更有利于宽带灯的进一步因素。
