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NABC1（BCAS1）：结直肠癌中的可变剪接与下调

NABC1 (BCAS1): alternative splicing and downregulation in colorectal tumors.

作者信息

Correa R G, de Carvalho A F, Pinheiro N A, Simpson A J, de Souza S J

机构信息

Ludwig Institute for Cancer Research, São Paulo, Brazil.

出版信息

Genomics. 2000 May 1;65(3):299-302. doi: 10.1006/geno.2000.6172.

DOI:10.1006/geno.2000.6172
PMID:10857754
Abstract

We have identified a new splicing variant of the gene "novel amplified in breast cancer 1," NABC1 (HGMW-approved symbol BCAS1). This variant, which we call NABC1_5B, uses a previously unidentified 135-bp exon. Also in this report, we confirm that NABC1 is overexpressed in breast tumors and show that both NABC1 and NABC1_5B are downregulated in colorectal tumors.

摘要

我们已经鉴定出基因“乳腺癌中新型扩增基因1”（NABC1，HGMW批准符号为BCAS1）的一种新的剪接变体。我们将这种变体称为NABC1_5B，它使用了一个先前未被识别的135碱基对外显子。在本报告中，我们还证实，NABC1在乳腺肿瘤中过表达，并且表明NABC1和NABC1_5B在结肠直肠肿瘤中均下调。

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