Zhang Jingzhe, Kai Li, Zhang Wenlong, Yin Yu, Wang Wenjun
a Department of Orthopedics , China-Japan Union Hospital Of Jilin University , Changchun130033, Jilin Province , China.
b Department of Anesthesiology , China-Japan Union Hospital Of Jilin University , Changchun130033, Jilin Province , China.
Cancer Biol Ther. 2018;19(11):994-997. doi: 10.1080/15384047.2018.1456607. Epub 2018 Jun 18.
Osteosarcoma (OS) is one of the most common bone malignancies in children and adolescents. To date, inaugural mechanism of OS was considered as a complex process and was still not clear. The p53 gene, most important tumor suppressors, was associated with risk of many tumors, including OS. In current study, we evaluated the relationship between genetic variation of the p53 binding site and the OS susceptibility through a two-stage case-control study in Chinese population. We found that rs1295925 (OR = 0.85; 95 CI = 0.76-0.94; P = 0.003) and rs3787547 (OR = 1.27; 95 CI = 1.11-1.45; P = 4.0 × 10) was significantly with OS susceptibility. Compared with those with rs1295925-TT genotype, and the risk of OS was significantly lower in individuals with CT genotype (OR = 0.77; 95 CI = 0.65-0.92) and CC genotype (OR = 0.75; 95 CI = 0.60-0.93). Compared with those with rs3787547-GG genotype, and the risk of OS was significantly higher in individuals with AG genotype (OR = 1.32; 95 CI = 1.10-1.58) and AA genotype (OR = 1.46; 95 CI = 1.11-1.92). To sum up, our results prove that SNP rs1295925 and rs3787547 play an important role in the etiology of OS, suggesting them as the potential genetic modifier for OS development.
骨肉瘤（OS）是儿童和青少年中最常见的骨恶性肿瘤之一。迄今为止，骨肉瘤的起始机制被认为是一个复杂的过程，仍不清楚。p53基因是最重要的肿瘤抑制基因，与包括骨肉瘤在内的多种肿瘤风险相关。在本研究中，我们通过一项针对中国人群的两阶段病例对照研究，评估了p53结合位点的基因变异与骨肉瘤易感性之间的关系。我们发现，rs1295925（比值比[OR]=0.85；95%置信区间[CI]=0.76 - 0.94；P = 0.003）和rs3787547（OR = 1.27；95%CI = 1.11 - 1.45；P = 4.0×10⁻⁴）与骨肉瘤易感性显著相关。与rs1295925 - TT基因型个体相比，CT基因型个体（OR = 0.77；95%CI = 0.65 - 0.92）和CC基因型个体（OR = 0.75；95%CI = 0.60 - 0.93）患骨肉瘤的风险显著降低。与rs3787547 - GG基因型个体相比，AG基因型个体（OR = 1.32；95%CI = 1.10 - 1.58）和AA基因型个体（OR = 1.46；95%CI = 1.11 - 1.92）患骨肉瘤的风险显著升高。综上所述，我们的结果证明单核苷酸多态性（SNP）rs1295925和rs3787547在骨肉瘤的病因学中起重要作用，提示它们可能是骨肉瘤发生发展的潜在基因修饰因子。
