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Association between SSRIs and upper gastrointestinal bleeding. Coprescription of antiulcer drugs with SSRIs is fairly common.选择性5-羟色胺再摄取抑制剂(SSRIs)与上消化道出血之间的关联。SSRIs与抗溃疡药物联合处方相当常见。
BMJ. 2000 May 20;320(7246):1405; author reply 1406.
2
Association between SSRIs and upper gastrointestinal bleeding. SSRIs are no more likely than other drugs to cause such bleeding.选择性5-羟色胺再摄取抑制剂(SSRI)与上消化道出血之间的关联。SSRI引发此类出血的可能性并不高于其他药物。
BMJ. 2000 May 20;320(7246):1405-6.
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Risk of upper gastrointestinal bleeding and the degree of serotonin reuptake inhibition by antidepressants: a case-control study.上消化道出血风险与抗抑郁药对5-羟色胺再摄取的抑制程度:一项病例对照研究。
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Use of selective serotonin reuptake inhibitors and risk of upper gastrointestinal tract bleeding: a population-based cohort study.选择性5-羟色胺再摄取抑制剂的使用与上消化道出血风险:一项基于人群的队列研究。
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Selective serotonin reuptake inhibitors and risk of upper GI bleeding: confusion or confounding?选择性5-羟色胺再摄取抑制剂与上消化道出血风险:混淆还是混杂?
Am J Med. 2006 Sep;119(9):719-27. doi: 10.1016/j.amjmed.2005.11.006.
6
Antidepressant drugs: a potential new drug cause of upper gastrointestinal bleeding.抗抑郁药:上消化道出血的一种潜在新型药物成因。
Dig Liver Dis. 2000 Aug-Sep;32(6):455-7. doi: 10.1016/s1590-8658(00)80000-6.
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Selective serotonin re-uptake inhibitors and the risk of bleeding.选择性5-羟色胺再摄取抑制剂与出血风险
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Association between SSRIs and upper gastrointestinal bleeding. Self treatment with non-steroidal drugs may be confounding factor.选择性5-羟色胺再摄取抑制剂(SSRIs)与上消化道出血之间的关联。使用非甾体类药物进行自我治疗可能是一个混杂因素。
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Interaction between selective serotonin reuptake inhibitors and nonsteroidal antiinflammatory drugs: review of the literature.选择性5-羟色胺再摄取抑制剂与非甾体抗炎药之间的相互作用:文献综述
Pharmacotherapy. 2006 Sep;26(9):1307-13. doi: 10.1592/phco.26.9.1307.
10
Depression drugs and GI bleeding.抗抑郁药物与胃肠道出血
Health News. 1999 Nov 20;5(14):5.

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Clinical Implications of Antidepressants and Associated Risk of Bleeding: A Narrative Review.抗抑郁药的临床意义及相关出血风险:一项叙述性综述。
Curr Pain Headache Rep. 2025 Jun 25;29(1):97. doi: 10.1007/s11916-025-01412-0.
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Antidepressant Prescription for Major Depressive Disorder: Results from a Population-Based Study in Italy.抗抑郁药治疗重度抑郁症:意大利一项基于人群的研究结果。
Curr Neuropharmacol. 2022 Nov 15;20(12):2381-2392. doi: 10.2174/1570159X20666220222142310.
3
Risk of serious upper gastrointestinal events with concurrent use of NSAIDs and SSRIs: a case-control study in the general population.非甾体抗炎药(NSAIDs)与选择性5-羟色胺再摄取抑制剂(SSRIs)联用导致严重上消化道事件的风险:一项普通人群中的病例对照研究
Eur J Clin Pharmacol. 2007 Apr;63(4):403-8. doi: 10.1007/s00228-007-0263-y. Epub 2007 Feb 14.
4
Combined use of SSRIs and NSAIDs increases the risk of gastrointestinal adverse effects.选择性5-羟色胺再摄取抑制剂(SSRIs)与非甾体抗炎药(NSAIDs)联合使用会增加胃肠道不良反应的风险。
Br J Clin Pharmacol. 2003 Jun;55(6):591-5. doi: 10.1046/j.0306-5251.2002.01770.x.
5
Inhibition of serotonin reuptake by antidepressants and upper gastrointestinal bleeding in elderly patients: retrospective cohort study.抗抑郁药对血清素再摄取的抑制作用与老年患者上消化道出血:回顾性队列研究
BMJ. 2001 Sep 22;323(7314):655-8. doi: 10.1136/bmj.323.7314.655.

本文引用的文献

1
Association between selective serotonin reuptake inhibitors and upper gastrointestinal bleeding: population based case-control study.选择性5-羟色胺再摄取抑制剂与上消化道出血之间的关联:基于人群的病例对照研究。
BMJ. 1999 Oct 23;319(7217):1106-9. doi: 10.1136/bmj.319.7217.1106.
2
Management of uninvestigated and functional dyspepsia: a Working Party report for the World Congresses of Gastroenterology 1998.未明确病因的功能性消化不良的管理:1998年世界胃肠病学大会工作小组报告
Aliment Pharmacol Ther. 1999 Sep;13(9):1135-48. doi: 10.1046/j.1365-2036.1999.00584.x.
3
Prescription-event and other forms of epidemiological monitoring of side-effects in the UK.英国的处方事件监测及其他形式的副作用流行病学监测。
Clin Exp Allergy. 1999 Jul;29 Suppl 3:217-39. doi: 10.1046/j.1365-2222.1999.0290s3217.x.
4
Community survey of factors associated with consultation for low back pain.腰痛咨询相关因素的社区调查
BMJ. 1998 Dec 5;317(7172):1564-7. doi: 10.1136/bmj.317.7172.1564.
5
Depression and depressive symptoms in rheumatoid arthritis patients: an analysis of their occurrence and determinants.类风湿关节炎患者的抑郁与抑郁症状:对其发生率及决定因素的分析
Br J Rheumatol. 1998 Apr;37(4):391-7. doi: 10.1093/rheumatology/37.4.391.
6
Over the counter drugs. GPs lack awareness of non-steroidal anti-inflammatory drugs available over the counter.非处方药。全科医生对非处方的非甾体抗炎药缺乏了解。
BMJ. 1996 Jul 13;313(7049):116. doi: 10.1136/bmj.313.7049.116a.
7
Vulnerability to perimenstrual mood change: the relevance of a past history of depressive disorder.经前情绪变化易感性:抑郁障碍既往史的相关性。
Psychosom Med. 1994 May-Jun;56(3):225-31. doi: 10.1097/00006842-199405000-00008.

Association between SSRIs and upper gastrointestinal bleeding. Coprescription of antiulcer drugs with SSRIs is fairly common.

作者信息

Williams D, Kelly A, Feely J

出版信息

BMJ. 2000 May 20;320(7246):1405; author reply 1406.

PMID:10858058
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1118062/
Abstract
摘要