携带该区域不同多态性的耐甲氧西林金黄色葡萄球菌分离株中mecA元件下游区域的基因组织
Genetic organization of the downstream region of the mecA element in methicillin-resistant Staphylococcus aureus isolates carrying different polymorphisms of this region.
作者信息
Oliveira D C, Wu S W, de Lencastre H
机构信息
Molecular Genetics Unit, Instituto de Tecnologia Química e Biológica da Universidade Nova de Lisboa, Oeiras, Portugal.
出版信息
Antimicrob Agents Chemother. 2000 Jul;44(7):1906-10. doi: 10.1128/AAC.44.7.1906-1910.2000.
Abstract
We describe here the genetic organization of the mec element downstream of the mecA gene in 34 different methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates carrying 13 of the most frequent polymorphisms of mecA and representing the major epidemic clones of MRSA. All polymorphisms carried three common genetic elements: the hypervariable region, a copy of IS431, and a unique 2-kb sequence (downstream constant segment, or dcs) for which no homologous sequences are found in data banks. Polymorphisms of the downstream region were shown to be caused by the presence of linearized plasmids flanked by insertion sequences (pUB110, pT181, and pI258) and the autonomous insertion sequence IS256.
摘要
我们在此描述了34种不同的耐甲氧西林金黄色葡萄球菌（MRSA）临床分离株中mecA基因下游mec元件的遗传组织情况，这些分离株携带mecA最常见的13种多态性，代表了MRSA的主要流行克隆。所有多态性均携带三个共同的遗传元件：高变区、一个IS431拷贝以及一个独特的2 kb序列（下游恒定片段，即dcs），数据库中未发现其同源序列。结果表明，下游区域的多态性是由侧翼为插入序列（pUB110、pT181和pI258）的线性化质粒以及自主插入序列IS256的存在所导致的。
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