Evaluation of bioartificial pancreas function made from sodium alginate and poly-L-lisine microcapsules settled with viable pancreatic islets.
作者信息
Gamian E, Kochman A, Rabczyński J
机构信息
Department of Pathological Anatomy, Medical University of Wrocław, Poland.
出版信息
Polim Med. 1999;29(3-4):3-20.
The possibility of transplantation of immuno-isolated viable pancreatic islets is a promising alternative for treatment diabetic patients. To establish the value of the artificial prosthesis made from settled with viable pancreatic islets microcapsulated using sodium alginate and poly-L-lisine, the glucose plasma levels were analyzed versus time after implantation into peritoneal cavity of rats or mice with alloxan-induced diabetes. The proper function of the bio-artificial pancreas manifested in normalization of glucose plasma level has been observed from 14 to 21 days after implantation in diabetic mice and rats.
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