van der Merwe S W, Attfield D, Fevery J, Bogaerde J B
Department of Experimental Hepatology and Department of Physiology, University of Pretoria, South Africa.
Med Hypotheses. 2000 May;54(5):842-5. doi: 10.1054/mehy.1999.0963.
Chronic liver disease is frequently complicated by bone disease. The mechanisms leading to bone-loss are unknown but are probably not related to abnormal vitamin D metabolism. The effects of portal hypertension and porto-systemic shunting on bone-loss have not been studied. It is postulated that liver disease, or the complications of liver disease (portal hypertension or porto-systemic shunting), might be responsible for the activation of cytokines. It is further postulated that these cytokines might be the final common pathway leading to bone-loss in both parenchymal and cholestatic liver disorders by modifying osteoblast or osteoclast function.
慢性肝病常并发骨病。导致骨质流失的机制尚不清楚，但可能与维生素D代谢异常无关。门静脉高压和门体分流对骨质流失的影响尚未得到研究。据推测，肝病或肝病并发症（门静脉高压或门体分流）可能导致细胞因子激活。进一步推测，这些细胞因子可能是通过改变成骨细胞或破骨细胞功能，导致实质和胆汁淤积性肝病骨质流失的最终共同途径。
