[紫苏提取物对F344大鼠的13周亚慢性经口毒性研究]

[A 13-week subchronic oral toxicity study of Perilla extracts in F344 rats].

作者信息

Yun L, Onodera H, Takagi H, Koujitani T, Yasuhara K, Mitsumori K, Hirose M

出版信息

Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku. 1999(117):104-7.

Abstract

A 13-week subchronic oral toxicity study of Perilla extracts in drinking water containing 0%, 2.5%, 5% and 10% extracts was performed in both sexes of F344 rats. Rats were randomly divided into 4 groups each consisting of 10 males and 10 females. No animals died during the period of administration. There were no treatment-related changes in body weight gain or in hematological or blood biochemistry values. Nor were any treatment-related histopathological changes observed in the highest dose group. These findings indicate that ingestion of 10% Perilla extracts in drinking water for 13-week does not cause any toxicological changes in rats.

摘要

在F344大鼠的雌雄两性中进行了一项为期13周的紫苏提取物亚慢性经口毒性研究，饮用水中提取物含量分别为0%、2.5%、5%和10%。大鼠被随机分为4组，每组10只雄性和10只雌性。给药期间无动物死亡。体重增加、血液学或血液生化值方面未出现与治疗相关的变化。在最高剂量组也未观察到任何与治疗相关的组织病理学变化。这些结果表明，大鼠饮用含10%紫苏提取物的水13周不会引起任何毒理学变化。