Nakamura H, Imazawa T, Nishikawa A, Furukawa F, Ikeda T, Miyauchi M, Hirose M
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku. 1999(117):119-22.
A 90-day subchronic toxicity study of Bacillus subtilis gum was performed in both sexes of F344 rats by feeding of CRF-1 pellet diet containing 0%, 0.18%, 0.55%, 1.66% and 5%. Rats were randomly allocated to 5 groups, each consisting of 10 males and females. No animals died during the administration period and no differences in body weights and food intakes were found among groups of either sex. Kidney weight was significantly increased in both sexes in the groups given concentrations of 1.66% or more. However, the increases of kidney weight were slight in themselves and other data on serum biochemistry and histopathology did not show any apparent toxicological signs including renal toxicity. These findings indicate that the treatment of Bacillus subtilis gum in the diet for 90 days does not exert serious toxicity in rats even at the highest dose.
通过给F344大鼠喂食含有0%、0.18%、0.55%、1.66%和5%枯草芽孢杆菌胶的CRF - 1颗粒饲料，对雌雄大鼠进行了为期90天的亚慢性毒性研究。大鼠被随机分为5组，每组雌雄各10只。给药期间无动物死亡，且各性别组间体重和食物摄入量均无差异。给予浓度为1.66%及以上的组中，雌雄大鼠的肾脏重量均显著增加。然而，肾脏重量的增加本身较为轻微，血清生化和组织病理学的其他数据未显示任何明显的毒理学迹象，包括肾毒性。这些发现表明，即使在最高剂量下，在饲料中添加枯草芽孢杆菌胶90天对大鼠也不会产生严重毒性。
