10头犊牛全心脏置换术后存活时间超过100小时的观察（作者译）

[Observation in 10 calves with a survival time of more than 100 hours after total heart replacement (author's transl)].

作者信息

Krautzberger W, Clevert D, Keilbach H, Kleine H O, Weidemann H, Grosse-Siestrup C, Affeld K, Henning E, Kless H, Mohnhaupt A, Mohnhaupt R, Unger V, Bücherl E S

出版信息

Thoraxchir Vask Chir. 1976 Aug;24(4):232-40. doi: 10.1055/s-0028-1095922.

DOI:10.1055/s-0028-1095922

PMID:1085998

Abstract

It is reported on 10 calves surviving total artificial heart replacement more than 100 hours. Pneumatically driven double-chambered blood pumps made of silastic were implanted. During the experiments an increase of the right atrial pressure as well as a rise of the perfusion volumes (CO) and of the blood volumes could be found regularly. At autopsy congestion of the organs especially of the liver was a regular finding. The changed hemodynamic is first seen as possible reason for this developments. The influence of anemia and the possible disturbances in the neurohumoral autoregulation of the animals by unphysiologic pressure curves are discussed.

摘要

据报道，10头小牛接受全人工心脏置换后存活超过100小时。植入了由硅橡胶制成的气动双腔血泵。在实验过程中，可定期发现右心房压力升高以及灌注量（心输出量）和血容量增加。尸检时，器官尤其是肝脏的充血是常见发现。血流动力学改变首先被视为这种情况发展的可能原因。讨论了贫血的影响以及非生理性压力曲线对动物神经体液自动调节可能产生的干扰。