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Head Neck. 2000 Jul;22(4):341-6. doi: 10.1002/1097-0347(200007)22:4<341::aid-hed5>3.0.co;2-3.
2
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Elevated protein kinase CK2 activity in chromatin of head and neck tumors: association with malignant transformation.头颈部肿瘤染色质中蛋白激酶CK2活性升高：与恶性转化的关联
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Downmodulation of TGF-alpha protein expression with antisense oligonucleotides inhibits proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells.用反义寡核苷酸下调转化生长因子α蛋白表达可抑制头颈部鳞状细胞癌的增殖，但对正常黏膜上皮细胞无此作用。
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Critical role of both p27KIP1 and p21CIP1/WAF1 in the antiproliferative effect of ZD1839 ('Iressa'), an epidermal growth factor receptor tyrosine kinase inhibitor, in head and neck squamous carcinoma cells.p27KIP1和p21CIP1/WAF1在表皮生长因子受体酪氨酸激酶抑制剂ZD1839（“易瑞沙”）对头颈部鳞状癌细胞的抗增殖作用中起关键作用。
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Silmitasertib, a casein kinase 2 inhibitor, induces massive lipid droplet accumulation and nonapoptotic cell death in head and neck cancer cells.西咪替塞替布，一种酪蛋白激酶2抑制剂，可诱导头颈部癌细胞中大量脂滴积累和非凋亡性细胞死亡。
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Protein kinase CK2 - diverse roles in cancer cell biology and therapeutic promise.蛋白激酶 CK2-在癌细胞生物学中的多种作用和治疗潜力。
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Protein Kinase CK2, a Potential Therapeutic Target in Carcinoma Management.蛋白激酶CK2，癌症治疗中的一个潜在治疗靶点。
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Preclinical In Vitro and In Vivo Evidence of an Antitumor Effect of CX-4945, a Casein Kinase II Inhibitor, in Cholangiocarcinoma.
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Bioorg Med Chem. 2017 Jul 1;25(13):3471-3482. doi: 10.1016/j.bmc.2017.04.037. Epub 2017 Apr 30.
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J Neuroinflammation. 2016 Jan 6;13:4. doi: 10.1186/s12974-015-0470-x.
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The casein kinase 2 inhibitor, CX-4945, as an anti-cancer drug in treatment of human hematological malignancies.酪蛋白激酶2抑制剂CX-4945作为一种治疗人类血液系统恶性肿瘤的抗癌药物。
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8
Mechanism and efficacy of sub-50-nm tenfibgen nanocapsules for cancer cell-directed delivery of anti-CK2 RNAi to primary and metastatic squamous cell carcinoma.小于50纳米的替恩菲基因纳米胶囊用于向原发性和转移性鳞状细胞癌进行癌细胞定向递送抗CK2 RNAi的机制与疗效
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Structural and functional insights into the regulation mechanism of CK2 by IP6 and the intrinsically disordered protein Nopp140.结构与功能揭示 IP6 和无规则卷曲蛋白 Nopp140 对 CK2 的调控机制。
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Nuclear hormone receptor corepressor promotes esophageal cancer cell invasion by transcriptional repression of interferon-γ-inducible protein 10 in a casein kinase 2-dependent manner.核激素受体共抑制因子通过依赖于酪蛋白激酶 2 的方式转录抑制干扰素-γ诱导蛋白 10 促进食管癌细胞侵袭。
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针对蛋白激酶CK2-α的反义寡核苷酸在体外抑制头颈部鳞状细胞癌的生长。

Antisense oligonucleotides against protein kinase CK2-alpha inhibit growth of squamous cell carcinoma of the head and neck in vitro.

作者信息

Faust R A, Tawfic S, Davis A T, Bubash L A, Ahmed K

机构信息

Department of Otolaryngology-Head & Neck Surgery, University of Minnesota, Minneapolis, USA.

出版信息

Head Neck. 2000 Jul;22(4):341-6. doi: 10.1002/1097-0347(200007)22:4<341::aid-hed5>3.0.co;2-3.

DOI:10.1002/1097-0347(200007)22:4<341::aid-hed5>3.0.co;2-3
PMID:10862016
Abstract

BACKGROUND

Human squamous cell carcinomas of the head and neck (SCCHN) overexpress the protein kinase CK2, and elevated CK2 activity correlates with aggressive tumor behavior and poor clinical outcome. We therefore investigated whether interference with CK2 expression would inhibit SCCHN cell growth in vitro.

METHODS

We targeted the catalytic (alpha) subunit of CK2 using an antisense oligodeoxynucleotide (ODN) strategy. Human Ca9-22 cells derived from SCCHN were transfected with CK2-alpha sense, nonsense, or antisense ODN; CK2 activity was measured; and the effect on CK2 activity and on cell growth was determined.

RESULTS

Transfection of Ca9-22 cells with antisense CK2-alpha ODN resulted in significantly decreased CK2 kinase activity associated with nuclear chromatin and in dose-dependent growth inhibition of Ca9-22 cells in vitro.

CONCLUSIONS

Interference with the protein kinase CK2 signal in SCCHN cells may offer a novel anticancer strategy for this malignancy.

摘要

背景

头颈部人类鳞状细胞癌（SCCHN）过度表达蛋白激酶CK2，CK2活性升高与肿瘤侵袭性行为及不良临床预后相关。因此，我们研究了干扰CK2表达是否会在体外抑制SCCHN细胞生长。

方法

我们采用反义寡脱氧核苷酸（ODN）策略靶向CK2的催化（α）亚基。用CK2-α正义、无义或反义ODN转染源自SCCHN的人Ca9-22细胞；测量CK2活性；并确定其对CK2活性和细胞生长的影响。

结果

用反义CK2-α ODN转染Ca9-22细胞导致与核染色质相关的CK2激酶活性显著降低，并在体外对Ca9-22细胞产生剂量依赖性生长抑制。

结论

干扰SCCHN细胞中的蛋白激酶CK2信号可能为这种恶性肿瘤提供一种新的抗癌策略。